(Q44047926)

English

Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).

scientific article published in July 2002

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scholarly article

1 reference

Europe PubMed Central

29 November 2017

Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). (English)

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Europe PubMed Central

29 November 2017

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apoptotic process

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author name string

Almenara J

1

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Europe PubMed Central

29 November 2017

Rosato R

2

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Europe PubMed Central

29 November 2017

Grant S

3

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Europe PubMed Central

29 November 2017

publication date

1 July 2002

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Europe PubMed Central

29 November 2017

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Europe PubMed Central

29 November 2017

16

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Europe PubMed Central

29 November 2017

1331-1343

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Europe PubMed Central

29 November 2017

7

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29 November 2017

https://scigraph.springernature.com/pub.10.1038/sj.leu.2402535

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Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate.

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Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

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Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

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Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

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Mechanisms of action of flavopiridol

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Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275

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Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies

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Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials

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Determination of flavopiridol (L86 8275; NSC 649890) in human plasma by reversed-phase liquid chromatography with electrochemical detection.

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Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.

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Effects of antisense p21 (WAF1/CIP1/MDA6) expression on the induction of differentiation and drug-mediated apoptosis in human myeloid leukemia cells (HL-60).

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Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01).

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Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

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Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release.

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The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway

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The control of phospholipid methylation by phorbol diesters in differentiating human myeloid HL-60 leukemia cells.

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Activation of protein kinase C relays distinct signaling pathways in the same cell type: differentiation and caspase-mediated apoptosis

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Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) in the reciprocal regulation of PKC activator-induced apoptosis and differentation in human myelomonocytic leukemia cells

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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

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Identifiers

10.1038/SJ.LEU.2402535

1 reference

Europe PubMed Central

29 November 2017

1 reference

Europe PubMed Central

29 November 2017

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