(Q44950735)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22349816%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

title

p53 is activated in response to disruption of the pre-mRNA splicing machinery (English)

1 reference

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23 January 2020

1

1 reference

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23 January 2020

Jean-Christophe Bourdon

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22349816%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

author name string

S Dayal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22349816%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

U Agarwala

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22349816%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

A Sparks

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22349816%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

M K Saville

6

1 reference

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23 January 2020

language of work or name

English

0 references

publication date

20 February 2012

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23 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22349816%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

volume

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22349816%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

issue

1

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23 January 2020

page(s)

1-14

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https://scigraph.springernature.com/pub.10.1038/onc.2012.38

23 January 2020

exact match

0 references

cites work

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Regulation of the p53 pathway by ubiquitin and related proteins

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Functions of MDMX in the modulation of the p53-response

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The p53 orchestra: Mdm2 and Mdmx set the tone

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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

21 January 2018

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DNA damage-induced MDMX degradation is mediated by MDM2.

21 January 2018

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Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation

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Spliceosome structure: piece by piece

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Structural studies of the spliceosome: blind men and an elephant

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The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine

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Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

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Alternative isoform regulation in human tissue transcriptomes

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Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology

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Alternative splicing: new insights from global analyses

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Alternative pre-mRNA splicing: the logic of combinatorial control

21 January 2018

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Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

21 January 2018

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Aberrant RNA splicing and its functional consequences in cancer cells

21 January 2018

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Entropy measures quantify global splicing disorders in cancer

21 January 2018

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A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer

21 January 2018

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The emerging role of splicing factors in cancer

21 January 2018

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Splicing factor SF3b as a target of the antitumor natural product pladienolide.

21 January 2018

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Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

21 January 2018

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Prp8 protein: at the heart of the spliceosome

21 January 2018

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Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast

21 January 2018

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Cross-talk in transcription, splicing and chromatin: who makes the first call?

21 January 2018

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Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.

21 January 2018

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A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding.

21 January 2018

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Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP

21 January 2018

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Molecular Architecture of the Multiprotein Splicing Factor SF3b

21 January 2018

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The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes

21 January 2018

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RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies

21 January 2018

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Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

21 January 2018

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Manipulation of alternative splicing by a newly developed inhibitor of Clks

21 January 2018

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Phosphorylation mechanism and structure of serine-arginine protein kinases

21 January 2018

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21 January 2018

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The transcription stress response

21 January 2018

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Contending with transcriptional arrest during RNAPII transcript elongation

21 January 2018

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The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing

21 January 2018

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Rates of in situ transcription and splicing in large human genes

21 January 2018

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Emerging roles of RNA and RNA-binding protein network in cancer cells

21 January 2018

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Cancer-associated regulation of alternative splicing

21 January 2018

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Insights into the connection between cancer and alternative splicing

21 January 2018

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A splicing factor that is inactivated during in vivo heat shock is functionally equivalent to the [U4/U6.U5] triple snRNP-specific proteins

21 January 2018

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Evidence of the modulation of mRNA splicing fidelity in humans by oxidative stress and p53.

21 January 2018

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Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo

21 January 2018

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An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

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An emerging role for nuclear RNA-mediated responses to genotoxic stress

21 January 2018

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

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ATM and ATR pathways signal alternative splicing of Drosophila TAF1 pre-mRNA in response to DNA damage

21 January 2018

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DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.

21 January 2018

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p53 isoforms can regulate p53 transcriptional activity.

21 January 2018

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Δ160p53 is a novel N-terminal p53 isoform encoded by Δ133p53 transcript.

21 January 2018

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Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.

21 January 2018

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Proofreading and spellchecking: a two-tier strategy for pre-mRNA splicing quality control

21 January 2018

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Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53

21 January 2018

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MdmX is a substrate for the deubiquitinating enzyme USP2a

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.38

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.38

Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.38

A regulatory role for CRM1 in the multi-directional trafficking of splicing snRNPs in the mammalian nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.38

Spliceosome Structure and Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.38

Exonic expression profiling of breast cancer and benign lesions: a retrospective analysis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.38

The SF3b155 N-terminal domain is a scaffold important for splicing

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.38