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p53 regulation by ubiquitin
scientific article published on 27 May 2011
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scholarly article
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Europe PubMed Central
PMCID
3172401
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24 August 2017
review article
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Europe PubMed Central
title
p53 regulation by ubiquitin
(English)
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Europe PubMed Central
PMCID
3172401
retrieved
24 August 2017
author name string
Christopher L Brooks
series ordinal
1
1 reference
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Europe PubMed Central
PMCID
3172401
retrieved
24 August 2017
Wei Gu
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
3172401
retrieved
24 August 2017
language of work or name
English
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publication date
27 May 2011
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stated in
Europe PubMed Central
PMCID
3172401
retrieved
24 August 2017
published in
FEBS Letters
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stated in
Europe PubMed Central
PMCID
3172401
retrieved
24 August 2017
volume
585
1 reference
stated in
Europe PubMed Central
PMCID
3172401
retrieved
24 August 2017
issue
18
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Europe PubMed Central
PMCID
3172401
retrieved
24 August 2017
page(s)
2803-2809
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Europe PubMed Central
PMCID
3172401
retrieved
24 August 2017
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USP10 regulates p53 localization and stability by deubiquitinating p53
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6 September 2017
A new map to understand deubiquitination
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Inactivation of HAUSP in vivo modulates p53 function
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6 September 2017
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6 September 2017
Modes of p53 regulation
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6 September 2017
Regulation of p53 family members by the ubiquitin-like SUMO system
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6 September 2017
Acetylation is indispensable for p53 activation
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6 September 2017
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.
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6 September 2017
Regulation of autophagy by cytoplasmic p53
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6 September 2017
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
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6 September 2017
The role of ubiquitination in the direct mitochondrial death program of p53.
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PubMed Central
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6 September 2017
Crippling p53 activities via knock-in mutations in mouse models
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6 September 2017
Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2
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PubMed Central
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6 September 2017
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
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PubMed Central
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6 September 2017
Monoubiquitylation promotes mitochondrial p53 translocation
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PubMed Central
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6 September 2017
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
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6 September 2017
Restoration of p53 function leads to tumour regression in vivo
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PubMed Central
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6 September 2017
Proteasome-independent functions of ubiquitin in endocytosis and signaling
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PubMed Central
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6 September 2017
Modeling the therapeutic efficacy of p53 restoration in tumors
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PubMed Central
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6 September 2017
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'
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PubMed Central
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6 September 2017
CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation
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PubMed Central
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6 September 2017
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.
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PubMed Central
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6 September 2017
FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity
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PubMed Central
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6 September 2017
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
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PubMed Central
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6 September 2017
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
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PubMed Central
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6 September 2017
The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis
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PubMed Central
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6 September 2017
Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo
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6 September 2017
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
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6 September 2017
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
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PubMed Central
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6 September 2017
Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development
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6 September 2017
Ubiquitination of p53 at multiple sites in the DNA-binding domain
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PubMed Central
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6 September 2017
Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo
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6 September 2017
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
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PubMed Central
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6 September 2017
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
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PubMed Central
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6 September 2017
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
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PubMed Central
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6 September 2017
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity
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6 September 2017
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
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6 September 2017
INK4a/ARF: a multifunctional tumor suppressor locus
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6 September 2017
Mdmx as an essential regulator of p53 activity
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6 September 2017
Ubiquitin: structures, functions, mechanisms
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6 September 2017
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.
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6 September 2017
The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type
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6 September 2017
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
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PubMed Central
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6 September 2017
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
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6 September 2017
Tumour suppression: disruption of HAUSP gene stabilizes p53
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6 September 2017
A dynamic role of HAUSP in the p53-Mdm2 pathway
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6 September 2017
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
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6 September 2017
Telomeres, stem cells, senescence, and cancer
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6 September 2017
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
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6 September 2017
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.
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6 September 2017
Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins
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6 September 2017
Polyubiquitination of p53 by a ubiquitin ligase activity of p300.
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6 September 2017
p53 has a direct apoptogenic role at the mitochondria
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6 September 2017
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
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6 September 2017
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
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6 September 2017
The nucleoporin RanBP2 has SUMO1 E3 ligase activity
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6 September 2017
C-terminal ubiquitination of p53 contributes to nuclear export
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6 September 2017
The INK4a/ARF network in tumour suppression
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6 September 2017
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
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6 September 2017
Mechanisms underlying ubiquitination
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6 September 2017
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.
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PubMed Central
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6 September 2017
Substrate targeting in the ubiquitin system
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PubMed Central
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6 September 2017
The ubiquitin system
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PubMed Central
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6 September 2017
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
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PubMed Central
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6 September 2017
Regulation of p53 stability by Mdm2
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PubMed Central
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6 September 2017
Mdm2 promotes the rapid degradation of p53
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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6 September 2017
A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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6 September 2017
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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6 September 2017
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
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PubMed Central
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6 September 2017
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
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PubMed Central
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6 September 2017
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation
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PubMed Central
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6 September 2017
NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways
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14 September 2017
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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14 September 2017
MSL2 promotes Mdm2-independent cytoplasmic localization of p53
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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14 September 2017
A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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14 September 2017
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
retrieved
14 September 2017
SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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14 September 2017
Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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14 September 2017
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
retrieved
14 September 2017
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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14 September 2017
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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14 September 2017
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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14 September 2017
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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14 September 2017
Inhibition of p53 degradation by Mdm2 acetylation
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stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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14 September 2017
Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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28 September 2017
Mdm2 and Mdm4 loss regulates distinct p53 activities
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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28 September 2017
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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1 September 2018
Phase I-II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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1 September 2018
Acetylation of p53 inhibits its ubiquitination by Mdm2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3172401
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1 September 2018
A phase I trial of intravenous infusion of ONYX-015 and enbrel in solid tumor patients
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21624367
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.FEBSLET.2011.05.022
1 reference
stated in
Europe PubMed Central
PMCID
3172401
retrieved
24 August 2017
PMCID
3172401
1 reference
stated in
Europe PubMed Central
PMCID
3172401
retrieved
24 August 2017
PubMed ID
21624367
1 reference
stated in
Europe PubMed Central
PMCID
3172401
retrieved
24 August 2017
ResearchGate publication ID
51176458
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