(Q24306428)

1

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Ning Kon

2

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Muyang Li

3

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Wenzhu Zhang

4

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Jun Qin

5

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Wei Gu

Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.

6

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language of work or name

English

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publication date

1 July 2005

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published in

Cell

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volume

121

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issue

7

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page(s)

1071-83

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cites work

1 reference

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7 January 2021

Functions of the MDM2 oncoprotein

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

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7 January 2021

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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7 January 2021

Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene

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7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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7 January 2021

New approaches to understanding p53 gene tumor mutation spectra

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7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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p53, the cellular gatekeeper for growth and division

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Parc: a cytoplasmic anchor for p53.

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7 January 2021

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

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7 January 2021

Human papillomavirus immortalization and transformation functions

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Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

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Tumor suppression by Ink4a-Arf: progress and puzzles

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From UBA to UBX: new words in the ubiquitin vocabulary.

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The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation

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The p53-Mdm2 module and the ubiquitin system.

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A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation

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p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

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Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

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7 January 2021

A dynamic role of HAUSP in the p53-Mdm2 pathway

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

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The MDM2 RING-finger domain is required to promote p53 nuclear export

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7 January 2021

Deacetylation of p53 modulates its effect on cell growth and apoptosis

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7 January 2021

Surfing the p53 network

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7 January 2021

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

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7 January 2021

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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7 January 2021

The INK4a/ARF network in tumour suppression

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7 January 2021

Cancer. p53, guardian of the genome

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7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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7 January 2021

Mdm2 promotes the rapid degradation of p53

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7 January 2021

Regulation of p53 stability by Mdm2

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7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

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7 January 2021

Tumour suppression: disruption of HAUSP gene stabilizes p53

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7 January 2021

The ubiquitin ligase COP1 is a critical negative regulator of p53

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7 January 2021

Live or let die: the cell's response to p53

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7 January 2021

Mdm2 association with p53 targets its ubiquitination

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7 January 2021

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

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7 January 2021

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

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7 January 2021

p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice

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7 January 2021

The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development

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7 January 2021

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

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7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity

1 reference

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7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

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7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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7 January 2021

Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage

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7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

p53-independent functions of the p19(ARF) tumor suppressor

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

ARF function does not require p53 stabilization or Mdm2 relocalization

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

Mechanisms underlying ubiquitination

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

Telomeres, stem cells, senescence, and cancer

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https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021

p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2005.03.037

7 January 2021