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Tumor suppression by Ink4a-Arf: progress and puzzles
scientific article (publication date: February 2003)
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scholarly article
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review article
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Europe PubMed Central
title
Tumor suppression by Ink4a-Arf: progress and puzzles
(English)
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author name string
Scott W Lowe
series ordinal
1
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Charles J Sherr
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2
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language of work or name
English
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publication date
February 2003
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published in
Current Opinion in Genetics & Development
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volume
13
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page(s)
77-83
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issue
1
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cites work
The INK4a/ARF network in tumour suppression
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7 January 2021
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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
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ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells
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Aging. When do telomeres matter?
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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
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Helper T cell differentiation is controlled by the cell cycle
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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
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INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence
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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.
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p16INK4A and p19ARF act in overlapping pathways in cellular immortalization
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Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages
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Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes
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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
1 reference
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inferred from DOI database lookup
Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
1 reference
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Modelling the molecular circuitry of cancer
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Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology
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Different telomere damage signaling pathways in human and mouse cells
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Benefits of bad telomeres
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7 January 2021
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Cellular senescence: mitotic clock or culture shock?
1 reference
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Crossref
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7 January 2021
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Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
1 reference
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Crossref
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7 January 2021
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Lack of replicative senescence in cultured rat oligodendrocyte precursor cells
1 reference
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Crossref
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Lack of replicative senescence in normal rodent glia
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression
1 reference
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Crossref
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7 January 2021
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Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
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Crossref
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Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a.
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E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest
1 reference
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Twist is a potential oncogene that inhibits apoptosis
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Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.
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p14ARF links the tumour suppressors RB and p53.
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7 January 2021
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Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry
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Network motifs in the transcriptional regulation network of Escherichia coli
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1 reference
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Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
1 reference
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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization
1 reference
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inferred from DOI database lookup
Dual inactivation of RB and p53 pathways in RAS-induced melanomas
1 reference
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Crossref
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inferred from DOI database lookup
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1 reference
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Crossref
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7 January 2021
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1 reference
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Crossref
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7 January 2021
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1 reference
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Crossref
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7 January 2021
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Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
p53-independent functions of the p19(ARF) tumor suppressor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900013-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.
1 reference
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Crossref
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7 January 2021
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1 reference
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7 January 2021
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1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900013-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Epidermal growth factor receptor and Ink4a/Arf
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900013-8
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7 January 2021
based on heuristic
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Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900013-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice.
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
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7 January 2021
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1 reference
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1 reference
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7 January 2021
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Identifiers
DOI
10.1016/S0959-437X(02)00013-8
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1924160
OpenCitations bibliographic resource ID
1924160
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1924160
PubMed ID
12573439
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1924160
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