(Q42797525)

7 November 2017

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. (English)

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7 November 2017

2

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7 November 2017

S D Boyd

1

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PubMed ID

10980695

7 November 2017

T Jacks

series ordinal

3

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7 November 2017

1 September 2000

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7 November 2017

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7 November 2017

2

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7 November 2017

563-568

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7 November 2017

9

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https://scigraph.springernature.com/pub.10.1038/35023500

7 November 2017

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cites work

p53, the cellular gatekeeper for growth and division

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7 January 2021

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

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7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

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7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

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7 January 2021

CRM1 is an export receptor for leucine-rich nuclear export signals

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7 January 2021

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

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7 January 2021

Evidence for a role of CRM1 in signal-mediated nuclear protein export

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7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

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7 January 2021

The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited

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7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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7 January 2021

Mdm2 promotes the rapid degradation of p53

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7 January 2021

Regulation of Mdm2-directed degradation by the C terminus of p53.

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7 January 2021

The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

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7 January 2021

MDM2 interacts with MDMX through their RING finger domains

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7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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7 January 2021

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway

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7 January 2021

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

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7 January 2021

Nuclear export of the small ribosomal subunit requires the ran-GTPase cycle and certain nucleoporins.

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7 January 2021

Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.

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7 January 2021

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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7 January 2021

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

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7 January 2021

Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation.

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7 January 2021

A function for monoubiquitination in the internalization of a G protein-coupled receptor.

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7 January 2021

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

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7 January 2021

SUMO-1 modification activates the transcriptional response of p53

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7 January 2021

Identification of a cryptic nucleolar-localization signal in MDM2

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7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

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7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

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7 January 2021

Identifiers

DOI

10.1038/35023500

1 reference

7 November 2017

1 reference

PubMed ID

10980695