(Q48111113)

8 February 2018

title

Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation (English)

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8 February 2018

author name string

A Zaika

series ordinal

1

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8 February 2018

N Marchenko

series ordinal

2

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8 February 2018

U M Moll

series ordinal

3

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8 February 2018

language of work or name

English

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publication date

1 September 1999

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8 February 2018

Journal of Biological Chemistry

published in

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8 February 2018

volume

274

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8 February 2018

issue

39

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8 February 2018

page(s)

27474-27480

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8 February 2018

Mdm2 promotes the rapid degradation of p53

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

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Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

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Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

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Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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Suppression of human colorectal carcinoma cell growth by wild-type p53

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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21 January 2018

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Human p53 expressed in baculovirus-infected Sf9 cells displays a two-dimensional isoform pattern identical to wild-type p53 from human cells

21 January 2018

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p53 is covalently linked to 5.8S rRNA.

21 January 2018

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Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

21 January 2018

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

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Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

21 January 2018

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The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Regulation of p53 function and stability by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

JNK targets p53 ubiquitination and degradation in nonstressed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

21 January 2018

Identifiers

DOI

10.1074/JBC.274.39.27474

1 reference

8 February 2018

1 reference

8 February 2018