(Q44966651)

7 December 2017

title

Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease (English)

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7 December 2017

6

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7 December 2017

Nghia Nguyen

1

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7 December 2017

Jessica A Bonzo

2

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7 December 2017

Shujuan Chen

3

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7 December 2017

Sarah Chouinard

4

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7 December 2017

Michael J Kelner

5

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7 December 2017

Alain Bélanger

7

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7 December 2017

Robert H Tukey

8

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7 December 2017

language of work or name

English

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publication date

7 January 2008

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Journal of Biological Chemistry

7 December 2017

published in

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7 December 2017

volume

283

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7 December 2017

issue

12

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7 December 2017

page(s)

7901-7911

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Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome

7 December 2017

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The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

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Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient

21 January 2018

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The blood-brain barrier and bilirubin encephalopathy

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Treatment of Crigler-Najjar type 1 disease: relevance of early liver transplantation

21 January 2018

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Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus

21 January 2018

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Human UDP-glucuronosyltransferases: metabolism, expression, and disease

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UDP-glucuronosyltransferase activity in human liver and colon

21 January 2018

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Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.

21 January 2018

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Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.

21 January 2018

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The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.

21 January 2018

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Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice

21 January 2018

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Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity

21 January 2018

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Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease

21 January 2018

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Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin

21 January 2018

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Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells

21 January 2018

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Microarray truths and consequences.

21 January 2018

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Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily

21 January 2018

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Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice.

21 January 2018

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Molecular cloning, expression and characterization of a monkey steroid UDP-glucuronosyltransferase, UGT2B19, that conjugates testosterone

21 January 2018

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Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.

21 January 2018

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UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S).

21 January 2018

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Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6.

21 January 2018

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The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

21 January 2018

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Identification of uridine diphosphate glucuronosyltransferases involved in the metabolism and clearance of mycophenolic acid

21 January 2018

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The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid

21 January 2018

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Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.

21 January 2018

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Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes

21 January 2018

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Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat

21 January 2018

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Cytokine induction of haem oxygenase mRNA in mouse liver. Interleukin 1 transcriptionally activates the haem oxygenase gene

21 January 2018

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The enzymes, regulation, and genetics of bile acid synthesis

21 January 2018

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Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.

21 January 2018

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

21 January 2018

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

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Effect of sodium phenobarbital on bilirubin metabolism in an infant with congenital, nonhemolytic, unconjugated hyperbilirubinemia, and kernicterus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709244200

Spectrum of UGT1A1 mutations in Crigler-Najjar (CN) syndrome patients: identification of twelve novel alleles and genotype-phenotype correlation

21 January 2018

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Bilirubin toxicity in the developing nervous system

21 January 2018

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Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons.

21 January 2018

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MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes

21 January 2018

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Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin.

21 January 2018

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p38 MAP kinase mediates bilirubin-induced neuronal death of cultured rat cerebellar granule neurons

21 January 2018

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Long term correction of bilirubin-UDP-glucuronosyltransferase deficiency in Gunn rats by administration of a recombinant adenovirus during the neonatal period

21 January 2018

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Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

21 January 2018

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Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin

21 January 2018

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Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709244200

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

21 January 2018

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Controlling false-negative errors in microarray differential expression analysis: a PRIM approach

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M709244200

21 January 2018

Identifiers

DOI

10.1074/JBC.M709244200

1 reference

7 December 2017

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