(Q45012762)

8 December 2017

title

Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling (English)

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8 December 2017

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8 December 2017

6

Roberto Bolli

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8 December 2017

Fadi N Salloum

2

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8 December 2017

Scott M Filippone

3

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8 December 2017

David E Durrant

4

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8 December 2017

Gregg Rokosh

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8 December 2017

Rakesh C Kukreja

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8 December 2017

publication date

25 April 2015

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Basic Research in Cardiology

8 December 2017

published in

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8 December 2017

volume

110

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8 December 2017

issue

3

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8 December 2017

page(s)

31

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Cardiac mTOR protects the heart against ischemia-reperfusion injury

8 December 2017

cites work

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One-year results of the SCORPIUS study: a German multicenter investigation on the effectiveness of sirolimus-eluting stents in diabetic patients

21 January 2018

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Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

21 January 2018

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The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation

21 January 2018

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A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning

21 January 2018

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Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.

21 January 2018

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ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice.

21 January 2018

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Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

21 January 2018

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Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta

21 January 2018

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AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition

21 January 2018

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The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion

21 January 2018

1 reference

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Regulating RISK: a role for JAK-STAT signaling in postconditioning?

21 January 2018

1 reference

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The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta

21 January 2018

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Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association

21 January 2018

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Cardioprotection: chances and challenges of its translation to the clinic

21 January 2018

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Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning

21 January 2018

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Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury

21 January 2018

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mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Diabetes increases mortality after myocardial infarction by oxidizing CaMKII

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Influence of diabetes mellitus on clinical outcome in the thrombolytic era of acute myocardial infarction. GUSTO-I Investigators. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries.

21 January 2018

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Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Targeting the mTOR signaling network for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Rapamycin attenuates load-induced cardiac hypertrophy in mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Increased CD36 expression in middle-aged mice contributes to obesity-related cardiac hypertrophy in the absence of cardiac dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Postconditioning inhibits myocardial apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Function of mitochondrial Stat3 in cellular respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

An essential role of the JAK-STAT pathway in ischemic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

Myocardial reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-015-0486-5

10.1007/S00395-015-0486-5

21 January 2018

Identifiers

DOI

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Dimensions Publication ID

8 December 2017

1050702236

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