(Q45013818)

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Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo

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Europe PubMed Central

PubMed publication ID

8 December 2017

Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

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3

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

author name string

Gabriele Weitz-Schmidt

1

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

Karl Welzenbach

2

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Europe PubMed Central

PubMed publication ID

8 December 2017

Joerg Kallen

4

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Europe PubMed Central

PubMed publication ID

8 December 2017

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publication date

10 August 2004

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Europe PubMed Central

PubMed publication ID

8 December 2017

number of pages

8

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

8 December 2017

279

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Europe PubMed Central

PubMed publication ID

8 December 2017

45

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

46764-46771

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Folding of the conserved domain but not of flanking regions in the integrin beta2 subunit requires association with the alpha subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

The immunological synapse: a molecular machine controlling T cell activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

A randomized multicenter trial comparing leukocyte function-associated antigen-1 monoclonal antibody with rabbit antithymocyte globulin as induction treatment in first kidney transplantations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Therapeutic antagonists and conformational regulation of integrin function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

1,4-Diazepane-2-ones as novel inhibitors of LFA-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Small molecule LFA-1 antagonists compete with an anti-LFA-1 monoclonal antibody for binding to the CD11a I domain: development of a flow-cytometry-based receptor occupancy assay.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Non-lipid-related effects of statins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Statins: the new aspirin?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Locking a leukocyte integrin with statins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Tackling multiple sclerosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

HMG-CoA reductase inhibitors as immunomodulators: potential use in transplant rejection.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407951200

21 January 2018

Identifiers

10.1074/JBC.M407951200

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

release_sq2l5y6s7vhmhaatnys7nr3f7i

1 reference

https://api.fatcat.wiki/v0/release/sq2l5y6s7vhmhaatnys7nr3f7i

24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

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