(Q44589706)

English

Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other

scientific article published in September 2003

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

author name string

Motomu Shimaoka

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Wei Yang

3

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Gabriele Weitz-Schmidt

4

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Timothy A Springer

5

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

language of work or name

0 references

publication date

1 September 2003

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

19

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

391-402

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Does the integrin alphaA domain act as a ligand for its betaA domain?

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of inflammation by collagen-binding integrins alpha1beta1 and alpha2beta1 in models of hypersensitivity and arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Recombinantly engineered human proteins: transforming the treatment of psoriasis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The immunological synapse: a molecular machine controlling T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The leukocyte integrins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1)

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha 4 integrin antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of I domain deletion on the function of the beta2 integrin lymphocyte function-associated antigen-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Intrinsic activating properties of GP IIb/IIIa blockers

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of humanized monoclonal antibody to rhesus CD11a in rhesus monkey cardiac allograft recipients

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Blockade of the integrin alphaLbeta2 but not of integrins alpha4 and/or beta7 significantly prolongs intestinal allograft survival in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Computational design of an integrin I domain stabilized in the open high affinity conformation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Conformational regulation of integrin structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Adhesion receptors of the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Predicted and experimental structures of integrins and beta-propellers

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Integrin activation and structural rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Sodium dodecyl sulfate-stable complexes of echistatin and RGD-dependent integrins: a novel approach to study integrins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of LFA-1 through a Ca2(+)-dependent epitope stimulates lymphocyte adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the extracellular segment of integrin alpha Vbeta3

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Folding and function of I domain-deleted Mac-1 and lymphocyte function-associated antigen-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Unusually stable and long-lived ligand-induced conformations of integrins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2803%2900238-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1074-7613(03)00238-3

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q44589706&oldid=2028799614"