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Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach

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8 December 2017

Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach (English)

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8 December 2017

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functional genomics

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based on heuristic

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Alexander Niculescu

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Niculescu AB

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8 December 2017

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Ogden CA

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8 December 2017

Rich ME

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8 December 2017

Schork NJ

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8 December 2017

Paulus MP

4

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8 December 2017

Geyer MA

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8 December 2017

Lohr JB

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Kuczenski R

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1 November 2004

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Molecular Psychiatry

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11

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8 December 2017

1007-1029

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8 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.mp.4001547

0 references

Are schizophrenic and bipolar disorders related? A review of family and molecular studies

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Time-dependent alterations in ICSS thresholds associated with repeated amphetamine administrations.

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Lithium and valproate protect against dextro-amphetamine induced brain choline concentration changes in bipolar disorder patients

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Acute and maintenance treatment with mood stabilizers

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Subgenual prefrontal cortex abnormalities in mood disorders.

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Differential regional zif268 messenger RNA expression in an escalating dose/binge model of amphetamine-induced psychosis

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The genetics of adult-onset neuropsychiatric disease: complexities and conundra?

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Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

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Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia

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Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders

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St John's wort and imipramine-induced gene expression profiles identify cellular functions relevant to antidepressant action and novel pharmacogenetic candidates for the phenotype of antidepressant treatment response

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Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: identification of a BAC contig spanning the translocation breakpoint at 7q21.

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Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22

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NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees

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Mu- and delta-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons

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Regulation by the neuropeptide cholecystokinin (CCK-8S) of protein phosphorylation in the neostriatum

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Glutamate transport, glutamine synthetase and phosphate-activated glutaminase in rat CNS white matter. A quantitative study

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Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

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Diverse psychotomimetics act through a common signaling pathway

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Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

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The neurobiology of slow synaptic transmission

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Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A

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Regulation of AMPA receptor dephosphorylation by glutamate receptor agonists

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Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine

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Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac).

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DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens

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Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice

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DARPP-32: regulator of the efficacy of dopaminergic neurotransmission

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Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia

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Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

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Substance P and affective disorders: new treatment opportunities by neurokinin 1 receptor antagonists?

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Exploring the opioid system by gene knockout

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Cholecystokinin antagonists a new way to improve the analgesia from old analgesics?

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Neuronal activity-dependent cell survival mediated by transcription factor MEF2

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Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation

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Regulation of gene expression and cocaine reward by CREB and ΔFosB

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Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis

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The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study.

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MRNA expression patterns and distribution of white matter neurons in dorsolateral prefrontal cortex of depressed patients differ from those in schizophrenia patients

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Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects

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Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge

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Tbr1 regulates differentiation of the preplate and layer 6.

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Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system

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Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia

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21 January 2018

Oligodendrocyte dysfunction in schizophrenia and bipolar disorder

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21 January 2018

Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21.

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21 January 2018

Neuropeptide Y Y(1) and Y(2) receptor mRNA expression in the prefrontal cortex of psychiatric subjects. Relationship of Y(2) subtype to suicidal behavior.

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21 January 2018

RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders

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Cholecystokinin in CSF from depressed patients: possible relations to severity of depression and suicidal behaviour.

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Enkephalin, dynorphin and substance P in postmortem substantia nigra from normals and schizophrenic patients.

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21 January 2018

Neurokinin-1 receptors are decreased in major depressive disorder.

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21 January 2018

Increased tachykinin NK(1) receptor immunoreactivity in the prefrontal cortex in schizophrenia.

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21 January 2018

Downregulation of neuronal cdk5/p35 in opioid addicts and opiate-treated rats: relation to neurofilament phosphorylation

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21 January 2018

Differential alteration of phospholipase A2 activities in brain of patients with schizophrenia.

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21 January 2018

Levels of mRNAs encoding synaptic vesicle and synaptic plasma membrane proteins in the temporal cortex of elderly schizophrenic patients

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21 January 2018

Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus

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21 January 2018

Cell biology of the hippocampal formation in schizophrenia

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21 January 2018

Abnormal cholecystokinin mRNA levels in entorhinal cortex of schizophrenics

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21 January 2018

A linkage disequilibrium study of bipolar disorder and microsatellite markers on 22q13.

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21 January 2018

Glutamine synthetase and glutamate dehydrogenase in the prefrontal cortex of patients with schizophrenia

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21 January 2018

Decreased prostaglandin synthesis in postmortem cerebral cortex from patients with Alzheimer's disease

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Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation.

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21 January 2018

Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23

1 reference

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The association of the D2S2944 124 bp allele with recurrent early onset major depressive disorder in women

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21 January 2018

Tau protein expression in frontotemporal dementias.

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21 January 2018

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.

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21 January 2018

Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X.

1 reference

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21 January 2018

Reduction of the synaptophysin level but normal levels of glycerophospholipids in the gyrus cinguli in schizophrenia.

1 reference

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21 January 2018

Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients

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21 January 2018

Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain.

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21 January 2018

Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease.

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21 January 2018

Synaptosomal proteins, beta-soluble N-ethylmaleimide-sensitive factor attachment protein (beta-SNAP), gamma-SNAP and synaptotagmin I in brain of patients with Down syndrome and Alzheimer's disease.

1 reference

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21 January 2018

Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortex

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21 January 2018

Frequent deletions at Xq28 indicate genetic heterogeneity in Hunter syndrome

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21 January 2018

A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci

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21 January 2018

Neuroleukin inhibition sensitises neuronal cells to caspase-dependent apoptosis

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21 January 2018

Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium

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21 January 2018

Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus.

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21 January 2018

Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

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21 January 2018

Cannabis-sensitive dopaminergic markers in postmortem central nervous system: changes in schizophrenia

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21 January 2018

Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia

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21 January 2018

Further postmortem autoradiographic studies of AMPA receptor binding in schizophrenia

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21 January 2018

Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21

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21 January 2018

14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains

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21 January 2018

Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia

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21 January 2018

Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder

1 reference

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21 January 2018

N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia

1 reference

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21 January 2018

Association and linkage analyses of RGS4 polymorphisms in schizophrenia

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21 January 2018

Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22.

1 reference

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21 January 2018

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling.

1 reference

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21 January 2018

Abnormal kainate receptor expression in prefrontal cortex in schizophrenia

1 reference

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21 January 2018

An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease.

1 reference

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21 January 2018

Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation

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21 January 2018

Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia.

1 reference

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21 January 2018

A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q

1 reference

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21 January 2018

A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes 9, 13 and 19

1 reference

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21 January 2018

Rapid-onset dystonia-parkinsonism: A clinical and genetic analysis of a new kindred

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21 January 2018

BDNF: a neuromodulator in nociceptive pathways?

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21 January 2018

Bayesian Theory

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21 January 2018

Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Finding genes for bipolar disorder in the functional genomics era: from convergent functional genomics to phenomics and back.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Brain SPECT Imaging of Amphetamine-Induced Dopamine Release in Euthymic Bipolar Disorder Patients

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Piecing together the puzzle of basal forebrain anatomy

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7 January 2021

based on heuristic

inferred from DOI database lookup

A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22–21, 4p16, 6q14–22, 10q26 and 16p13.3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Diminished anxiety- and depression-related behaviors in mice with selective deletion of the Tac1 gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Global expression-profiling studies and oligodendrocyte dysfunction in schizophrenia and bipolar disorder

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Suicide risk and treatments for patients with bipolar disorder

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Myocyte-specific enhancer binding factor 2C expression in human brain development

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7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuronal expression of glutamine synthetase in Alzheimer's disease indicates a profound impairment of metabolic interactions with astrocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Alterations in phosphoinositide signaling and G-protein levels in depressed suicide brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Genome wide scan using homozygosity mapping and linkage analyses of a single pedigree with affective disorder suggests oligogenic inheritance.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Glycogen synthase kinase-3beta, beta-catenin, and tau in postmortem bipolar brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Anterior cingulate cortex pathology in schizophrenia and bipolar disorder.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001547

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.MP.4001547

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

ResearchGate publication ID

0 references

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