(Q45048681)

22 May 2018

title

Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system (English)

1 reference

22 May 2018

3

B R Blackman

1 reference

22 May 2018

author name string

A Dash

1

1 reference

22 May 2018

R A Figler

2

1 reference

22 May 2018

S Marukian

4

1 reference

22 May 2018

M S Collado

5

1 reference

22 May 2018

M J Lawson

6

1 reference

22 May 2018

S A Hoang

7

1 reference

22 May 2018

A J Mackey

8

1 reference

22 May 2018

D Manka

9

1 reference

22 May 2018

B K Cole

10

1 reference

22 May 2018

R E Feaver

11

1 reference

22 May 2018

A J Sanyal

12

1 reference

22 May 2018

B R Wamhoff

13

1 reference

22 May 2018

publication date

7 December 2016

1 reference

22 May 2018

published in

Toxicology in Vitro

1 reference

22 May 2018

volume

39

1 reference

22 May 2018

page(s)

93-103

1 reference

22 May 2018

Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis

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25 May 2018

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Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

25 May 2018

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Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis

25 May 2018

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ROAST: rotation gene set tests for complex microarray experiments

25 May 2018

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25 May 2018

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edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

25 May 2018

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Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression

25 May 2018

1 reference

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Model-based analysis of ChIP-Seq (MACS)

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

Simultaneous inference in general parametric models

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

Precision-cut tissue slices as a tool to predict metabolism of novel drugs.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

Cytochromes P450, drugs, and diseases

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

Ultrastructural changes in hepatocytes of precision-cut rat liver slices after incubation for 24 and 48 hours.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems

25 May 2018

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25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype

25 May 2018

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25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

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25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

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25 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

Dynamic organ culture of precision liver slices for in vitro toxicology.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation

25 May 2018

1 reference

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A novel mouse model of nonalcoholic steatohepatitis with significant insulin resistance

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

Precision-cut liver slices: a tool to model the liver ex vivo.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5191970

Treatment of nonalcoholic fatty liver disease

15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27939613

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

NASH animal models: are we there yet?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27939613

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.TIV.2016.11.014

1 reference

22 May 2018

release_i5u2kf7prfckxdn24qodjcy3ty

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/i5u2kf7prfckxdn24qodjcy3ty

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

5191970

1 reference

22 May 2018

PubMed publication ID

27939613

1 reference

22 May 2018