(Q45081425)

9 December 2017

The microglia-activating potential of thrombin: the protease is not involved in the induction of proinflammatory cytokines and chemokines (English)

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9 December 2017

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1

Uwe-Karsten Hanisch

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9 December 2017

Denise van Rossum

2

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9 December 2017

Yiheng Xie

3

1 reference

9 December 2017

Klaus Gast

4

1 reference

9 December 2017

Rolf Misselwitz

5

1 reference

9 December 2017

Seppo Auriola

6

1 reference

9 December 2017

Gundars Goldsteins

7

1 reference

9 December 2017

Jari Koistinaho

8

1 reference

9 December 2017

Helmut Kettenmann

9

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9 December 2017

Thomas Möller

10

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9 December 2017

language of work or name

English

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publication date

27 September 2004

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Journal of Biological Chemistry

9 December 2017

8

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based on heuristic

inferred from page(s)

published in

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9 December 2017

279

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9 December 2017

51880-51887

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9 December 2017

50

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Serine proteases and brain damage - is there a link?

9 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Cellular consequences of thrombin-receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Thrombin signalling and protease-activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Thrombin signaling in the brain: the role of protease-activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Protease-activated receptors: sentries for inflammation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Thrombin induces IL-10 production in microglia as a negative feedback regulator of TNF-alpha release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Protein oxidation and heme oxygenase-1 induction in porcine white matter following intracerebral infusions of whole blood or plasma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

T cell-mediated neuroprotection involves antithrombin activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Acute tissue damage after injections of thrombin and plasmin into rat striatum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Identification of a peptide sequence in albumin that potentiates superoxide production by microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

A serum factor enhances production of nitric oxide and tumor necrosis factor-alpha from cultured microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Microglia as a source and target of cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Microglia as neuroprotective, immunocompetent cells of the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Expression of proteinase-activated receptors in mouse microglial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Microglial activation by components of gram-positive and -negative bacteria: distinct and common routes to the induction of ion channels and cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Interaction of site specific hirudin variants with alpha-thrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Thrombin: a potential proinflammatory mediator in neurotrauma and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Prothrombin kringle-2 activates cultured rat brain microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

The cleaved peptide of the thrombin receptor is a strong platelet agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Protease activated receptors: theme and variations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

The thrombin receptor in the nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Thrombin accumulation in brains of patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Expression of factor X in both the rat brain and cells of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Fibroblasts, glial, and neuronal cells are involved in extravascular prothrombin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

A molecular mechanism for synapse elimination: novel inhibition of locally generated thrombin delays synapse loss in neonatal mouse muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Proteases involved in long-term potentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Thrombin may contribute to the pathophysiology of central nervous system injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

Isolation of recombinant hirudin by preparative high-performance liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408318200

21 January 2018

Identifiers

DOI

10.1074/JBC.M408318200

1 reference

9 December 2017

1 reference