(Q45084776)

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Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network.

scientific article published on 29 September 2004

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scholarly article

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3 January 2020

Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network (English)

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3 January 2020

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Sandra Wiley

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Jeremy Copp

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3 January 2020

Peter van der Geer

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29 September 2004

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3 January 2020

American Journal of Physiology - Cell Physiology

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3 January 2020

C403-15

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3 January 2020

2

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3 January 2020

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Critical contribution of linker proteins to Raf kinase activation

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Death receptors: signaling and modulation

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

How renal cells handle urea

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

The SH3 and BH domains of the p85alpha adapter subunit play a critical role in regulating class Ia phosphoinositide 3-kinase function

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

The adenine nucleotide translocator in apoptosis

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Inositol trisphosphate and calcium signalling

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Increasing complexity of Ras signaling.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Stress kinase p38 mediates EGFR transactivation by hyperosmolar concentrations of sorbitol

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Positive and negative regulation of Raf kinase activity and function by phosphorylation

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Urea-inducible Egr-1 transcription in renal inner medullary collecting duct (mIMCD3) cells is mediated by extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Cell cycle delay and apoptosis in response to osmotic stress.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

The use of hypertonic saline in the treatment of traumatic brain injury

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

An osmosensing signal transduction pathway in mammalian cells.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Apoptotic pathways: the roads to ruin

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Signaling--2000 and beyond

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Mitogen-activated protein kinase and its activator are regulated by hypertonic stress in Madin-Darby canine kidney cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Connecting signaling and cell cycle progression in growth factor-stimulated cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

The activation of phosphatidylinositol 3-kinase by Ras

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Activators and effectors of ras p21 proteins

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Signal transduction. How receptors turn Ras on.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Mitochondrial dysfunction is an early event in high-NaCl-induced apoptosis of mIMCD3 cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

The complexity of Raf-1 regulation

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Hyperosmotic stress activates the insulin receptor in CHO cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Mitochondria and programmed cell death: back to the future.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Cell signaling by receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Effects of hypertonic (10%) saline in patients with raised intracranial pressure after stroke

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Conspiracy theory: RAS and RAF do not act alone

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Hyperosmotic stress-induced apoptosis and tau phosphorylation in human neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Cell cycle-dependent activation of Ras.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Hyperosmolality activates Akt and regulates apoptosis in renal tubular cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

CNK, a RAF-binding multidomain protein required for RAS signaling

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Ras signaling in the inner medullary cell response to urea and NaCl

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Merging mitochondria matters: cellular role and molecular machinery of mitochondrial fusion

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Urea protects from the proapoptotic effect of NaCl in renal medullary cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

PI3K signaling in the murine kidney inner medullary cell response to urea

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00095.2004

21 January 2018

Identifiers

10.1152/AJPCELL.00095.2004

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15456696%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15456696%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

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