(Q45086491)

9 December 2017

title

Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells (English)

1 reference

9 December 2017

3

David Mittelman

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9 December 2017

Vera Gorbunova

1

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9 December 2017

Andrei Seluanov

series ordinal

2

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9 December 2017

John H Wilson

series ordinal

4

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9 December 2017

publication date

30 September 2004

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9 December 2017

published in

Human Molecular Genetics

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9 December 2017

volume

13

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9 December 2017

issue

23

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9 December 2017

page(s)

2979-2989

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DNA repeat expansions and human disease

9 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Analysis of DNA replication intermediates suggests mechanisms of repeat sequence expansion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Recombination-induced CAG trinucleotide repeat expansions in yeast involve the MRE11-RAD50-XRS2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Trinucleotide expansion in haploid germ cells by gap repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Mitotic stability of fragile X mutations in differentiated cells indicates early post-conceptional trinucleotide repeat expansion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Gametic but not somatic instability of CAG repeat length in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Huntington disease expansion mutations in humans can occur before meiosis is completed

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Slipping while sleeping? Trinucleotide repeat expansions in germ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Epigenetic reprogramming in mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

The contribution of <i>cis</i>-elements to disease-associated repeat instability: clinical and experimental evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

CpG methylation modifies the genetic stability of cloned repeat sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Characterization of the full fragile X syndrome mutation in fetal gametes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Demethylation, reactivation, and destabilization of human fragile X full-mutation alleles in mouse embryocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Unusual mutations in high functioning fragile X males: apparent instability of expanded unmethylated CGG repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Age at onset in Huntington's disease and methylation at D4S95

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

A study of DNA methylation in myotonic dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

The DMPK gene of severely affected myotonic dystrophy patients is hypermethylated proximal to the largely expanded CTG repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Efficient modification of the APRT gene by FLP/FRT site-specific targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Cell cycle effects and cellular pharmacology of 5-AZA-2?-deoxycytidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

TFT and 6TG resistance of mouse lymphoma cells to analogs of azacytidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Histone acetylation is required to maintain the unfolded nucleosome structure associated with transcribing DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Genetic assays for measuring rates of (CAG).(CTG) repeat instability in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Trinucleotide repeat instability: a hairpin curve at the crossroads of replication, recombination, and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Analysis of germline mutation spectra at the Huntington's disease locus supports a mitotic mutation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

De novo expansion of intermediate alleles in spinocerebellar ataxia 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Increased trinucleotide repeat instability with advanced maternal age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Allele-specific non-CpG methylation of the Nf1 gene during early mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

C(m)C(a/t)GG methylation: a new epigenetic mark in mammalian DNA?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Reexpression of a cluster of silenced transgenes is associated with their rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

DNA hypomethylation leads to elevated mutation rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Suppression of crossing-over by DNA methylation in Ascobolus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Cytosine methylation and the ecology of intragenomic parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

Analysis of full fragile X mutations in fetal tissues and monozygotic twins indicate that abnormal methylation and somatic heterogeneity are established early in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDH317

21 January 2018

Identifiers

DOI

10.1093/HMG/DDH317

1 reference

release_2lklor5lzrbghcc4tehzq57iua

9 December 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2lklor5lzrbghcc4tehzq57iua

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference