(Q45112972)

9 December 2017

title

Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy (English)

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9 December 2017

main subject

Plasmodium falciparum

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7

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9 December 2017

A Levi Omara-Opyene

1

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9 December 2017

Pedro A Moura

2

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9 December 2017

Carlos R Sulsona

3

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9 December 2017

J Alfredo Bonilla

4

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9 December 2017

Charles A Yowell

5

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9 December 2017

Hisashi Fujioka

6

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9 December 2017

John B Dame

8

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9 December 2017

language of work or name

English

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publication date

18 October 2004

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Journal of Biological Chemistry

9 December 2017

published in

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9 December 2017

volume

279

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9 December 2017

issue

52

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9 December 2017

page(s)

54088-54096

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Antimalarial drug discovery: efficacy models for compound screening

9 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Activity and inhibition of plasmepsin IV, a new aspartic proteinase from the malaria parasite, Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. infecting man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Generation of hemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Plasmodium falciparum falcilysin: an unprocessed food vacuole enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Fate of haem iron in the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Plasmodium hemozoin formation mediated by histidine-rich proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

The structure of malaria pigment beta-haematin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Intraerythrocytic Plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Excess haemoglobin digestion by malaria parasites: a strategy to prevent premature host cell lysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

The plasmodium digestive vacuole: metabolic headquarters and choice drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Proteases of malaria parasites: new targets for chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Human malaria parasites in continuous culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Culture of human malaria parasites Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Rapid isolation of DNA from trypanosomatid protozoa using a simple 'mini-prep' procedure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Role for the plasmodium falciparum digestive vacuole in chloroquine resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Identification of mouse liver proteins on two-dimensional electrophoresis gels by matrix-assisted laser desorption/ionization mass spectrometry of in situ enzymatic digests

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Molecular cloning, characterization and overexpression of two distinct cysteine protease cDNAs from Leishmania donovani chagasi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

New potent C2-symmetric malaria plasmepsin I and II inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Recombinant expression and enzymatic subsite characterization of plasmepsin 4 from the four Plasmodium species infecting man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Discovery of gene function by expression profiling of the malaria parasite life cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Structural insights into the activation of P. vivax plasmepsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409605200

21 January 2018

Identifiers

DOI

10.1074/JBC.M409605200

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9 December 2017

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