(Q35790381)

10 August 2017

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title

Antimalarial drug discovery: efficacy models for compound screening (English)

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10 August 2017

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2

Philip J Rosenthal

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10 August 2017

1

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author name string

Simon L Croft

series ordinal

3

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10 August 2017

Reto Brun

series ordinal

4

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10 August 2017

Solomon Nwaka

series ordinal

5

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10 August 2017

publication date

1 June 2004

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Nature Reviews Drug Discovery

10 August 2017

published in

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10 August 2017

volume

3

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10 August 2017

issue

6

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10 August 2017

page(s)

509-520

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10 August 2017

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21 January 2018

The treatment of malaria

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The structure of malaria pigment beta-haematin

21 January 2018

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Chloroquine resistance in the malarial parasite, Plasmodium falciparum

21 January 2018

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Chloroquine-resistant malaria

21 January 2018

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Monitoring antimalarial drug resistance: making the most of the tools at hand

21 January 2018

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Systematic review of amodiaquine treatment in uncomplicated malaria

21 January 2018

1 reference

Modern chemotherapeutic options for malaria

21 January 2018

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The development of Lapdap, an affordable new treatment for malaria

21 January 2018

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Medical need, scientific opportunity and the drive for antimalarial drugs

21 January 2018

1 reference

Virtual drug discovery and development for neglected diseases through public-private partnerships

21 January 2018

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Malaria: Current status of control, diagnosis, treatment, and a proposed agenda for research and development

21 January 2018

1 reference

Prevention of Increasing Rates of Treatment Failure by Combining Sulfadoxine‐Pyrimethamine with Artesunate or Amodiaquine for the Sequential Treatment of Malaria

21 January 2018

1 reference

Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial

21 January 2018

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Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial

21 January 2018

1 reference

Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study

21 January 2018

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Averting a malaria disaster

21 January 2018

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Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial

21 January 2018

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Artemether-lumefantrine for the treatment of multidrug-resistant falciparum malaria

21 January 2018

1 reference

Cysteine proteases of malaria parasites: targets for chemotherapy

21 January 2018

1 reference

Protein farnesyltransferase and protein prenylation in Plasmodium falciparum

21 January 2018

1 reference

Parasitology. Drugs to combat tropical protozoan parasites

21 January 2018

1 reference

The apicoplast as an antimalarial drug target

21 January 2018

1 reference

Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

21 January 2018

1 reference

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

21 January 2018

1 reference

21 January 2018

Fosmidomycin for malaria

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Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

21 January 2018

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Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase

21 January 2018

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Antimalarial chemotherapy: young guns or back to the future?

21 January 2018

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Genome sequence of the human malaria parasite Plasmodium falciparum

21 January 2018

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Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine

21 January 2018

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Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil

21 January 2018

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Expression of a Plasmodium gene introduced into subtelomeric regions of Plasmodium berghei chromosomes.

21 January 2018

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Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress.

21 January 2018

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Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

21 January 2018

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Transfection of malaria parasites.

21 January 2018

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DNA microarrays for malaria

21 January 2018

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The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum

21 January 2018

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Discovery of gene function by expression profiling of the malaria parasite life cycle

21 January 2018

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Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry

21 January 2018

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A proteomic view of the Plasmodium falciparum life cycle

21 January 2018

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A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

21 January 2018

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Malaria drug-sensitivity testing: new assays, new perspectives

21 January 2018

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Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria

21 January 2018

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Inoculum effect with chloroquine and Plasmodium falciparum

21 January 2018

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A Method for Testing for Synergy with Any Number of Agents

21 January 2018

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Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro

21 January 2018

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The production of mature gametocytes of Plasmodium falciparum in continuous cultures of different isolates infective to mosquitoes

21 January 2018

1 reference

Developmental arrest of the human malaria parasite Plasmodium falciparum within the mosquito midgut via CTRP gene disruption

21 January 2018

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Human malaria in immunocompromised mice: new in vivo model for chemotherapy studies

21 January 2018

1 reference

Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy

21 January 2018

1 reference

The chemotherapy of rodent malaria. LVII. Drug combinations to impede the selection of drug resistance, Part 1: Which model is appropriate?

21 January 2018

1 reference

A class of potent antimalarials and their specific accumulation in infected erythrocytes

21 January 2018

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Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites

21 January 2018

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Hit and lead generation: beyond high-throughput screening

21 January 2018

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Profiling drug-like properties in discovery research

21 January 2018

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Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data

21 January 2018

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Insights into antifolate resistance from malarial DHFR-TS structures

21 January 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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Role of the development scientist in compound lead selection and optimization

21 January 2018

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The common technical document: the changing face of the New Drug Application.

21 January 2018

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Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum

21 January 2018

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Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania

21 January 2018

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Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum

21 January 2018

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Antimalarial activity of new gossypol derivatives

21 January 2018

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Characterization of an eukaryotic peptide deformylase from Plasmodium falciparum

21 January 2018

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Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes.

21 January 2018

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A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.

21 January 2018

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Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases

21 January 2018

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Artemisinins target the SERCA of Plasmodium falciparum

21 January 2018

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New malaria chemotherapy developed by utilization of a unique parasite transport system

21 January 2018

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Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.

21 January 2018

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Structure-activity relationships for antiplasmodial activity among 7-substituted 4-aminoquinolines.

21 January 2018

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Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum

21 January 2018

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Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II.

21 January 2018

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Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones

21 January 2018

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Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes

21 January 2018

1 reference

Malaria: new chemotherapeutic peroxide drugs

21 January 2018

1 reference

Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.

21 January 2018

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Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity

21 January 2018

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Proteases involved in erythrocyte invasion by the malaria parasite: function and potential as chemotherapeutic targets

21 January 2018

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Plasmodium falciparum: in vitro interactions of artemisinin with amodiaquine, pyronaridine, and chloroquine

21 January 2018

1 reference

The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice

21 January 2018

1 reference

The Plasmodium genome database

21 January 2018

1 reference

The safety and efficacy of sulfadoxine-pyrimethamine, amodiaquine, and their combination in the treatment of uncomplicated Plasmodium falciparum malaria

21 January 2018

1 reference

The de novo selection of drug-resistant malaria parasites

31 March 2020

1 reference

Determination of fifty percent inhibitory concentrations (IC50) of antimalarial drugs against Plasmodium falciparum parasites in a serum-free medium.

31 March 2020

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Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro

31 March 2020

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Comparison of in vitro and in vivo antimalarial activities of 9-phenanthrenecarbinols.

31 March 2020

1 reference

Lead generation--enhancing the success of drug discovery by investing in the hit to lead process

31 March 2020

1 reference

Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase.

31 March 2020

1 reference

The chemotherapy of rodent malaria. LV. Interactions between pyronaridine and artemisinin.

31 March 2020

1 reference

Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1416

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10 August 2017

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