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Medical need, scientific opportunity and the drive for antimalarial drugs
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11832957
retrieved
2 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Medical need, scientific opportunity and the drive for antimalarial drugs
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11832957
retrieved
2 August 2017
main subject
antimalarial
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author name string
Robert G Ridley
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11832957
retrieved
2 August 2017
language of work or name
English
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publication date
1 February 2002
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Europe PubMed Central
PubMed ID
11832957
retrieved
2 August 2017
published in
Nature
1 reference
stated in
Europe PubMed Central
PubMed ID
11832957
retrieved
2 August 2017
volume
415
1 reference
stated in
Europe PubMed Central
PubMed ID
11832957
retrieved
2 August 2017
page(s)
686-693
1 reference
stated in
Europe PubMed Central
PubMed ID
11832957
retrieved
2 August 2017
issue
6872
1 reference
stated in
Europe PubMed Central
PubMed ID
11832957
retrieved
2 August 2017
exact match
https://scigraph.springernature.com/pub.10.1038/415686a
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cites work
Thalidomide: current and potential clinical applications
1 reference
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Chloroquine-resistant malaria
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Crossref
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Dihydrofolate reductase and antifolate resistance in malaria
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Crossref
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4-Aminoquinolines--past, present, and future: a chemical perspective
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Crossref
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Artemisinin drugs: novel antimalarial agents
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F415686A
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7 January 2021
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Artemisinin and derivatives: the future for malaria treatment?
1 reference
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Crossref
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7 January 2021
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Assessment of the pharmacodynamic properties of antimalarial drugs in vivo
1 reference
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Crossref
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Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine
1 reference
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Arteether-induced brain injury in Macaca mulatta. I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei.
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Severe allergic reactions to oral artesunate: a report of two cases
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Crossref
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Desbutyl-benflumetol, a novel antimalarial compound: in vitro activity in fresh isolates of Plasmodium falciparum from Thailand
1 reference
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Crossref
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In vitro activity of lumefantrine (benflumetol) against clinical isolates of Plasmodium falciparum in Yaoundé, Cameroon.
1 reference
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Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria
1 reference
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Crossref
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Cost-effectiveness of sulfadoxine-pyrimethamine for the prevention of malaria-associated low birth weight.
1 reference
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Crossref
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Therapeutic efficacy of sulphadoxine/pyrimethamine and susceptibility in vitro of P. falciparum isolates to sulphadoxine-pyremethamine and other antimalarial drugs in Malawian children
1 reference
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Crossref
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Drug resistance in malaria
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Crossref
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Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group
1 reference
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Crossref
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A plastid organelle as a drug target in apicomplexan parasites.
1 reference
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Crossref
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Antimalarial drug development and new targets
1 reference
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Crossref
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Emerging targets for antimalarial drugs
1 reference
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A brief illustrated guide to the ultrastructure of Plasmodium falciparum asexual blood stages
1 reference
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Hemoglobin metabolism in the malaria parasite Plasmodium falciparum
1 reference
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Crossref
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Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets.
1 reference
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Crossref
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Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum
1 reference
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Crossref
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Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum
1 reference
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The structure of malaria pigment beta-haematin
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Crossref
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Ferriprotoporphyrin IX fulfills the criteria for identification as the chloroquine receptor of malaria parasites
1 reference
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Crossref
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On the molecular mechanism of chloroquine's antimalarial action
1 reference
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Crossref
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Access to hematin: the basis of chloroquine resistance.
1 reference
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Crossref
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A common mechanism for blockade of heme polymerization by antimalarial quinolines
1 reference
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Crossref
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The chemical basis for the ferriprotoporphyrin IX-chloroquine complex induced lipid peroxidation
1 reference
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Crossref
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Chloroquine - some open questions on its antimalarial mode of action and resistance
1 reference
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Crossref
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Possible modes of action of the artemisinin-type compounds.
1 reference
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Crossref
reference URL
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Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
1 reference
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Crossref
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Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria.
1 reference
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Crossref
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Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum
1 reference
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1 reference
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Crossref
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1 reference
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Crossref
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Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores
1 reference
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Crossref
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Reversal of chloroquine resistance in Plasmodium falciparum by verapamil
1 reference
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Crossref
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A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum
1 reference
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Crossref
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Enhanced efficacy of chloroquine-chlorpheniramine combination in acute uncomplicated falciparum malaria in children
1 reference
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Crossref
reference URL
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inferred from DOI database lookup
A plastid of probable green algal origin in Apicomplexan parasites.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F415686A
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7 January 2021
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Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F415686A
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Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
1 reference
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Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum
1 reference
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Crossref
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Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
1 reference
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Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
1 reference
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Mitochondria of mammalian Plasmodium spp.
1 reference
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Phenyl beta-methoxyacrylates: a new antimalarial pharmacophore.
1 reference
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Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs
1 reference
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Crossref
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1 reference
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Crossref
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The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F415686A
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An overview of chemotherapeutic targets for antimalarial drug discovery
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F415686A
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1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F415686A
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1 reference
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Membrane transport in the malaria-infected erythrocyte
1 reference
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Crossref
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A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite.
1 reference
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Crossref
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Proteases involved in erythrocyte invasion by the malaria parasite: function and potential as chemotherapeutic targets
1 reference
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Crossref
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7 January 2021
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An overview of Plasmodium protein kinases.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F415686A
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7 January 2021
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The role of genomics in antibacterial target discovery
1 reference
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Crossref
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7 January 2021
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Advances in structural genomics
1 reference
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Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine
1 reference
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https://api.crossref.org/works/10.1038%2F415686A
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7 January 2021
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Transfection of malaria parasites.
1 reference
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7 January 2021
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Plasmodium: drug discovery and development--an industrial perspective
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F415686A
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7 January 2021
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Role of the development scientist in compound lead selection and optimization
1 reference
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https://api.crossref.org/works/10.1038%2F415686A
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7 January 2021
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
1 reference
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https://api.crossref.org/works/10.1038%2F415686A
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7 January 2021
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A new global commitment to disease control in Africa
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retrieved
7 January 2021
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Identifiers
DOI
10.1038/415686A
1 reference
stated in
Europe PubMed Central
PubMed ID
11832957
retrieved
2 August 2017
Dimensions Publication ID
1049965895
0 references
PubMed ID
11832957
1 reference
stated in
Europe PubMed Central
PubMed ID
11832957
retrieved
2 August 2017
ResearchGate publication ID
11527687
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