(Q35050387)

6 August 2017

title

Emerging targets for antimalarial drugs (English)

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6 August 2017

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Govinarajan Padmanaban

series ordinal

1

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6 August 2017

Pundi N Rangarajan

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

1 August 2001

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Expert Opinion on Therapeutic Targets

6 August 2017

published in

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6 August 2017

volume

5

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6 August 2017

issue

4

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6 August 2017

page(s)

423-441

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Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Utilization of exogenous folate in the human malaria parasite Plasmodium falciparum and its critical role in antifolate drug synergy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Properties and substrate specificity of a purine phosphoribosyltransferase from the human malaria parasite, Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Pyrimidine biosynthesis in parasitic protozoa: purification of a monofunctional dihydroorotase from Plasmodium berghei and Crithidia fasciculata.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Identification of hemoglobin degradation products in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Plasmepsin II, an acidic hemoglobinase from the Plasmodium falciparum food vacuole, is active at neutral pH on the host erythrocyte membrane skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

In vitro antimalarial activity of chalcones and their derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Conservation of key amino acids among the cysteine proteinases of multiple malarial species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Hemin lyses malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Haemozoin: identification and quantification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

The structure of malaria pigment beta-haematin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Formation of haemozoin/beta-haematin under physiological conditions is not spontaneous

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Haem polymerization in malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Plasmodium hemozoin formation mediated by histidine-rich proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Heme metabolism of Plasmodium is a major antimalarial target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

A common mechanism for blockade of heme polymerization by antimalarial quinolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Chloroquine inhibits heme-dependent protein synthesis in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Reversed siderophores act as antimalarial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Identification of a chloroquine importer in Plasmodium falciparum. Differences in import kinetics are genetically linked with the chloroquine-resistant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

A molecular marker for chloroquine-resistant falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Reversal of chloroquine resistance in Plasmodium falciparum by verapamil

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Import of host delta-aminolevulinate dehydratase into the malarial parasite: identification of a new drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Apicomplexan plastids as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Impact of a plastid-bearing endocytobiont on apicomplexan genomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Developmental stage-specific biosynthesis of glycosylphosphatidylinositol anchors in intraerythrocytic Plasmodium falciparum and its inhibition in a novel manner by mannosamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Plasmodium falciparum exports the Golgi marker sphingomyelin synthase into a tubovesicular network in the cytoplasm of mature erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

A membrane network for nutrient import in red cells infected with the malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Characterisation of the gene encoding adenylosuccinate lyase of Plasmodium falciparum1Note: Nucleotide sequence data reported in this paper available in the GenBank™ data base under the accession number U84403.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

Optical and radiocarbon dating at Jinmium rock shelter in northern Australia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.4.423

21 January 2018

Identifiers

DOI

10.1517/14728222.5.4.423

1 reference

6 August 2017

1 reference