(Q45118374)

9 December 2017

An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells (English)

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9 December 2017

Naoyuki Nishiya

1

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9 December 2017

William B Kiosses

series ordinal

2

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9 December 2017

Jaewon Han

series ordinal

3

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9 December 2017

Mark H Ginsberg

series ordinal

4

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9 December 2017

27 March 2005

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9 December 2017

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9 December 2017

7

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9 December 2017

343-352

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9 December 2017

4

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https://scigraph.springernature.com/pub.10.1038/ncb1234

9 December 2017

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cites work

Cell migration: a physically integrated molecular process

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7 January 2021

Cell migration: integrating signals from front to back

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7 January 2021

Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

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7 January 2021

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

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7 January 2021

Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

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7 January 2021

Rho GTPases and the actin cytoskeleton

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7 January 2021

Rho GTPases control polarity, protrusion, and adhesion during cell movement

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7 January 2021

Localized Rac activation dynamics visualized in living cells

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7 January 2021

Conserved microtubule-actin interactions in cell movement and morphogenesis

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7 January 2021

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

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7 January 2021

VLA proteins in the integrin family: structures, functions, and their role on leukocytes

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7 January 2021

Differential requirements for alpha4 integrins during fetal and adult hematopoiesis

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7 January 2021

Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses

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7 January 2021

Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding

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7 January 2021

Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin

1 reference

7 January 2021

Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration

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7 January 2021

The paxillin LD motifs

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7 January 2021

Paxillin and focal adhesion signalling

1 reference

7 January 2021

Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex

1 reference

7 January 2021

The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling

1 reference

7 January 2021

Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase

1 reference

7 January 2021

Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase

1 reference

7 January 2021

The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL).

1 reference

7 January 2021

Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

1 reference

7 January 2021

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

1 reference

7 January 2021

EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization

1 reference

7 January 2021

Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D

1 reference

7 January 2021

A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration

1 reference

7 January 2021

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

1 reference

7 January 2021

ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA.

1 reference

7 January 2021

Activation of Rac and Cdc42 by integrins mediates cell spreading

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7 January 2021

Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway

1 reference

7 January 2021

Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

1 reference

7 January 2021

The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways

1 reference

7 January 2021

Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation

1 reference

7 January 2021

ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma

1 reference

7 January 2021

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

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7 January 2021

alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

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7 January 2021

Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains

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7 January 2021

The alpha4 subunit of integrin is important for neural crest cell migration.

1 reference

7 January 2021

Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment

1 reference

7 January 2021

Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression.

1 reference

7 January 2021

GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex

1 reference

7 January 2021

Src kinase activation by direct interaction with the integrin β cytoplasmic domain

1 reference

7 January 2021

Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion

1 reference

7 January 2021

Identifiers

DOI

10.1038/NCB1234

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Dimensions Publication ID

9 December 2017

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