(Q45128222)

9 December 2017

title

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA. (English)

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9 December 2017

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20

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9 December 2017

24

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9 December 2017

Markus Müller

23

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Fabio Spada

object named as

Fabio Spada

2

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Primo Schär

object named as

Primo Schär

22

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Stylianos Michalakis

12

object named as

Stylianos Michalakis

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9 December 2017

Toni Pfaffeneder

1

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9 December 2017

Mirko Wagner

3

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9 December 2017

Caterina Brandmayr

4

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9 December 2017

Silvia K Laube

5

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9 December 2017

David Eisen

6

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9 December 2017

Matthias Truss

7

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9 December 2017

Jessica Steinbacher

8

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9 December 2017

Benjamin Hackner

9

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9 December 2017

Olga Kotljarova

10

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9 December 2017

David Schuermann

11

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9 December 2017

Olesea Kosmatchev

13

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9 December 2017

Stefan Schiesser

14

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9 December 2017

Barbara Steigenberger

15

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9 December 2017

Nada Raddaoui

16

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9 December 2017

Gengo Kashiwazaki

17

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9 December 2017

Udo Müller

18

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9 December 2017

Cornelia G Spruijt

19

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9 December 2017

Heinrich Leonhardt

21

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9 December 2017

publication date

18 May 2014

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9 December 2017

published in

Nature Chemical Biology

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9 December 2017

volume

10

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9 December 2017

issue

7

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9 December 2017

page(s)

574-581

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https://scigraph.springernature.com/pub.10.1038/nchembio.1532

9 December 2017

exact match

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cites work

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

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The discovery of 5-formylcytosine in embryonic stem cell DNA.

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

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Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

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Tet family proteins and 5-hydroxymethylcytosine in development and disease

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Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites

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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

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AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.

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DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells

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Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

21 January 2018

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The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

21 January 2018

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Quantification of the sixth DNA base hydroxymethylcytosine in the brain

21 January 2018

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Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA.

21 January 2018

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FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency

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Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells

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Naive pluripotency is associated with global DNA hypomethylation

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Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells

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A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation

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21 January 2018

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21 January 2018

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21 January 2018

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Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1

21 January 2018

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Uracil in DNA--general mutagen, but normal intermediate in acquired immunity

21 January 2018

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Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

21 January 2018

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21 January 2018

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DNA modifications repaired by base excision repair are epigenetic.

21 January 2018

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Deamination, oxidation, and C-C bond cleavage reactivity of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine

21 January 2018

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Click Chemistry as a Reliable Method for the High-Density Postsynthetic Functionalization of Alkyne-Modified DNA

21 January 2018

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Collisionally activated dissociation of protonated 2'-deoxycytidine, 2'-deoxyuridine, and their oxidatively damaged derivatives

21 January 2018

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Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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12 December 2020

Surviving an Oxygen Atmosphere: DNA Damage and Repair

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12 December 2020

Serologic Assay of DNA Base Damage: I. 5-Hydroxymethyldeoxyuridine, A Radiation Product of Thymidine

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12 December 2020

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

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12 December 2020

Oxidation of thymine to 5-formyluracil in DNA: mechanisms of formation, structural implications, and base excision by human cell free extracts

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1532

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Dimensions Publication ID

9 December 2017

1038572510

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1 reference