(Q45157847)

10 December 2017

title

Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors (English)

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10 December 2017

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1

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10 December 2017

4

Zeger Debyser

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Frauke Christ

series ordinal

5

object named as

Frauke Christ

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10 December 2017

3

Maurizio Botta

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10 December 2017

Cristina Tintori

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10 December 2017

publication date

14 February 2012

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Journal of Biomolecular Screening

10 December 2017

published in

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10 December 2017

volume

17

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10 December 2017

issue

5

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10 December 2017

page(s)

618-628

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Integrase and integration: biochemical activities of HIV-1 integrase

10 December 2017

cites work

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https://api.crossref.org/works/10.1177%2F1087057111436343

Structural insights into the retroviral DNA integration apparatus.

21 January 2018

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Structural biology of retroviral DNA integration

21 January 2018

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Transportin-SR2 imports HIV into the nucleus

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

Raltegravir: a review of its pharmacokinetics, pharmacology and clinical studies

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

Resistance associated mutations to dolutegravir (S/GSK1349572) in HIV-infected patients--impact of HIV subtypes and prior raltegravir experience.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

Allosteric inhibitor development targeting HIV-1 integrase

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111436343

Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111436343

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111436343

Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111436343

Luminescent oxygen channeling immunoassay: measurement of particle binding kinetics by chemiluminescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111436343

Rapid microtiter assays for poxvirus topoisomerase, mammalian type IB topoisomerase and HIV-1 integrase: application to inhibitor isolation

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057111436343

A pair of new statistical parameters for quality control in RNA interference high-throughput screening assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111436343

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111436343

Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111436343

21 January 2018

Identifiers

DOI

10.1177/1087057111436343

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10 December 2017

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