(Q45217845)

10 December 2017

title

Nuclear export of adenovirus E4orf6 protein is necessary for its ability to antagonize apoptotic activity of BH3-only proteins (English)

1 reference

10 December 2017

1 reference

1 reference

proto-oncogene protein

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534539

tumor suppressor proteins

19 March 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534539

19 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206743

19 March 2024

4

Akiko Takahashi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534539

19 March 2024

author name string

Mariko Aoyagi

1

1 reference

10 December 2017

Fumihiro Higashino

2

1 reference

10 December 2017

Motoaki Yasuda

3

1 reference

10 December 2017

Yukiharu Sawada

5

1 reference

10 December 2017

Yasunori Totsuka

6

1 reference

10 December 2017

Takao Kohgo

7

1 reference

10 December 2017

Hidehiko Sano

8

1 reference

10 December 2017

Masanobu Kobayashi

9

1 reference

10 December 2017

Masanobu Shindoh

10

1 reference

10 December 2017

language of work or name

English

0 references

publication date

1 October 2003

1 reference

10 December 2017

9 October 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14534539

full work available at URL

19 March 2024

https://www.nature.com/articles/1206743.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534539

https://www.nature.com/articles/1206743.pdf

19 March 2024

file format

Portable Document Format

1 reference

DOI

https://api.crossref.org/works/10.1038/SJ.ONC.1206743

https://www.nature.com/articles/1206743

19 March 2024

1 reference

DOI

https://api.crossref.org/works/10.1038/SJ.ONC.1206743

19 March 2024

1 reference

10 December 2017

volume

22

1 reference

10 December 2017

issue

44

1 reference

10 December 2017

page(s)

6919-6927

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206743

10 December 2017

exact match

0 references

cites work

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Inactivation of p53 gene in human and murine osteosarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

The C. elegans orthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

A potential NES of the Epstein-Barr virus nuclear antigen 1 (EBNA1) does not confer shuttling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Mitochondria and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

BCL-2 family members and the mitochondria in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Association of adenovirus early-region 1A proteins with cellular polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Adenovirus-mediated transfer of p53-related genes induces apoptosis of human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

The carboxy terminal C-tail of BNip3 is crucial in induction of mitochondrial permeability transition in isolated mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Oncogenic potential of the adenovirus E4orf6 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Two distinct activities contribute to the oncogenic potential of the adenovirus type 5 E4orf6 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

The adenovirus E4orf6 protein contributes to malignant transformation by antagonizing E1A-induced accumulation of the tumor suppressor protein p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Bcl-2 and the regulation of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Bcl-2 family: life-or-death switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

The nuclear export signal within the E4orf6 protein of adenovirus type 5 supports virus replication and cytoplasmic accumulation of viral mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

7 January 2021

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

7 January 2021

An arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

7 January 2021

Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

7 January 2021

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

7 January 2021

The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

7 January 2021

Regulation of apoptosis by viral gene products

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

7 January 2021

Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206743

7 January 2021

Identifiers

DOI

1 reference

Dimensions Publication ID

10 December 2017

1018202010

0 references

1 reference