(Q45231223)

11 December 2017

title

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice (English)

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11 December 2017

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Christian Haass

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Anja Capell

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Anja Capell

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Christine Van Broeckhoven

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Christine Van Broeckhoven

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Gernot Kleinberger

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Jonathan Laflamme Janssen

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Jonathan Janssens

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Ivy Cuijt

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Peter P De Deyn

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Hans Wils

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Sandra Pereson

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Debby Van Dam

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Geert Joris

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11 December 2017

publication date

25 June 2012

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11 December 2017

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volume

228

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11 December 2017

issue

1

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page(s)

67-76

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

11 December 2017

cites work

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Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

21 January 2018

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Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis

21 January 2018

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Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

21 January 2018

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Progranulin and TDP-43: mechanistic links and future directions

21 January 2018

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Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

21 January 2018

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The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice

21 January 2018

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

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Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations

21 January 2018

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Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

21 January 2018

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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

21 January 2018

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Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

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Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies

21 January 2018

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Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls

21 January 2018

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Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging

21 January 2018

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The ubiquitin proteasome system in neuropathology

21 January 2018

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Brain lipopigment accumulation in normal and pathological aging

21 January 2018

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

21 January 2018

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Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy

21 January 2018

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Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

21 January 2018

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The insulin/IGF-1 signaling in mammals and its relevance to human longevity

21 January 2018

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The granulin/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro.

21 January 2018

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Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene.

21 January 2018

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Core features of frontotemporal dementia recapitulated in progranulin knockout mice

21 January 2018

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Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

21 January 2018

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Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

21 January 2018

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Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development.

21 January 2018

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Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models

21 January 2018

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Pigments in aging: an overview

21 January 2018

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21 January 2018

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Cellular localization of gene expression for progranulin

21 January 2018

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Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish.

21 January 2018

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Modulation of extracellular matrix by nutritional hepatotrophic factors in thioacetamide-induced liver cirrhosis in the rat.

21 January 2018

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Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

21 January 2018

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Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures

21 January 2018

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PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification

21 January 2018

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Characterization of ubiquitinated intraneuronal inclusions in a novel Belgian frontotemporal lobar degeneration family.

21 January 2018

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Synaptic dysfunction in progranulin-deficient mice

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21 January 2018

Identifiers

DOI

10.1002/PATH.4043

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11 December 2017

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