(Q45296306)

11 December 2017

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title

The role of apoptosis in neurodegenerative diseases (English)

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11 December 2017

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P Desjardins

1

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PubMed ID

9699918

11 December 2017

S Ledoux

series ordinal

2

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11 December 2017

1 June 1998

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11 December 2017

Metabolic Brain Disease

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11 December 2017

13

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11 December 2017

79-96

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11 December 2017

2

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https://scigraph.springernature.com/pub.10.1023/a:1020605112755

11 December 2017

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cites work

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

1 reference

12 December 2020

The biochemistry of programmed cell death

1 reference

12 December 2020

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

1 reference

12 December 2020

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

12 December 2020

Apoptotic cell death induced by beta-amyloid 1-42 peptide is cell type dependent

1 reference

12 December 2020

Vitamin E protects nerve cells from amyloid beta protein toxicity

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12 December 2020

Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid

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12 December 2020

Protease activation during apoptosis: death by a thousand cuts?

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12 December 2020

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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12 December 2020

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

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12 December 2020

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

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12 December 2020

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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12 December 2020

Social controls on cell survival and cell death

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12 December 2020

Apoptosis, oncosis, and necrosis. An overview of cell death

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12 December 2020

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

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12 December 2020

Role of the mitochondrial permeability transition pore in apoptosis

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12 December 2020

Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons

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12 December 2020

Oxidative stress, glutamate, and neurodegenerative disorders

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12 December 2020

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

1 reference

12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

Transcriptional activation modulated by homopolymeric glutamine and proline stretches

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12 December 2020

Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons

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12 December 2020

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

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12 December 2020

Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons

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12 December 2020

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

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12 December 2020

Use of genetic and physical mapping to locate the spinal muscular atrophy locus between two new highly polymorphic DNA markers

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12 December 2020

Dopamine-induced apoptosis is inhibited in PC12 cells expressing Bcl-2

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12 December 2020

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

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12 December 2020

Glutamate-dopamine interactions in the basal ganglia: relationship to Parkinson's disease

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12 December 2020

In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes

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12 December 2020

Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity

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12 December 2020

Histochemical detection of apoptosis in Parkinson's disease.

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12 December 2020

Life and death decisions: the role of the IAPs in modulating programmed cell death

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12 December 2020

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

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12 December 2020

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

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12 December 2020

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

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12 December 2020

Oxidative stress induces apoptosis in embryonic cortical neurons.

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12 December 2020

Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action

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12 December 2020

Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy

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12 December 2020

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

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12 December 2020

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

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12 December 2020

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

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12 December 2020

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

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12 December 2020

Excitotoxic cell death

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12 December 2020

Peroxynitrite-induced cytotoxicity in PC12 cells: evidence for an apoptotic mechanism differentially modulated by neurotrophic factors

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12 December 2020

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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12 December 2020

Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity

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12 December 2020

Hydrogen peroxide mediates amyloid beta protein toxicity

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12 December 2020

Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

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12 December 2020

Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis.

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12 December 2020

Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement

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12 December 2020

Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli.

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12 December 2020

Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells.

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12 December 2020

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

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12 December 2020

Bcl-x(L) forms an ion channel in synthetic lipid membranes.

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12 December 2020

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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12 December 2020

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

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12 December 2020

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

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12 December 2020

Human ICE/CED-3 protease nomenclature

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12 December 2020

Alzheimer's disease and soluble A beta

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12 December 2020

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

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12 December 2020

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

1 reference

12 December 2020

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

1 reference

12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

12 December 2020

Induction and activation of tissue transglutaminase during programmed cell death

1 reference

12 December 2020

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease

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12 December 2020

Modulation of control mechanisms of dopamine-induced apoptosis--a future approach to the treatment of Parkinson's disease?

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12 December 2020

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

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12 December 2020

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

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12 December 2020

Apoptosis. A sticky business.

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12 December 2020

Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection

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12 December 2020

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

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12 December 2020

Toward an understanding of the molecular mechanisms of physiological cell death.

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12 December 2020

Apoptosis in C3H/10T1/2 mouse embryonic cells: evidence for internucleosomal DNA modification in the absence of double-strand cleavage

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12 December 2020

Role of astrocytes in MPTP metabolism and toxicity

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12 December 2020

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

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12 December 2020

S100beta induces neuronal cell death through nitric oxide release from astrocytes

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12 December 2020

Apoptosis, excitotoxicity, and neuropathology

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12 December 2020

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

12 December 2020

DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay.

1 reference

12 December 2020

The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death

1 reference

12 December 2020

Molecular cloning of the interleukin-1 beta converting enzyme

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12 December 2020

Cell death induced by beta-amyloid 1-40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis

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12 December 2020

Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain

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12 December 2020

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

12 December 2020

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

12 December 2020

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

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12 December 2020

Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin.

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12 December 2020

Life, death, and the pursuit of apoptosis.

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12 December 2020

Apoptosis in neurological disease

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12 December 2020

Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy

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12 December 2020

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

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12 December 2020

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

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12 December 2020

p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells.

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12 December 2020

A radical hypothesis for neurodegeneration

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12 December 2020

Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis

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12 December 2020

Oxygen radicals as key mediators in neurological disease: fact or fiction?

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12 December 2020

Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis

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12 December 2020

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

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12 December 2020

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

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12 December 2020

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

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12 December 2020

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

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12 December 2020

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

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12 December 2020

DNA end labeling (TUNEL) in Huntington's disease and other neuropathological conditions

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12 December 2020

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

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12 December 2020

Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts

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12 December 2020

Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons

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12 December 2020

Programmed cell death and Bcl-2 protection in the absence of a nucleus

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12 December 2020

In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note

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12 December 2020

Programmed cell death in the developing nervous system

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12 December 2020

Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease

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12 December 2020

Amyloid beta peptide induces necrosis rather than apoptosis.

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12 December 2020

Superoxide dismutases

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12 December 2020

Evidence for apoptotic cell death in Alzheimer's disease.

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12 December 2020

Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35.

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12 December 2020

Inhibition of ATP synthesis by 1-methyl-4-phenylpyridinium ion (MPP+) in isolated mitochondria from mouse brains.

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12 December 2020

Identification and characterization of a spinal muscular atrophy-determining gene

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12 December 2020

Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation.

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12 December 2020

Inactivation of the mouse Huntington's disease gene homolog Hdh

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12 December 2020

Astrocytes and Parkinson's disease

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12 December 2020

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation

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12 December 2020

Human genetic diseases due to codon reiteration: relationship to an evolutionary mechanism

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12 December 2020

Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos

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12 December 2020

Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis.

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12 December 2020

Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology

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12 December 2020

Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

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12 December 2020

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

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12 December 2020

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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12 December 2020

A cautionary note on the use of the TUNEL stain to determine apoptosis

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12 December 2020

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

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12 December 2020

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

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12 December 2020

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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12 December 2020

In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: correlations with senile plaques and disease progression.

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12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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12 December 2020

Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.

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12 December 2020

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

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12 December 2020

In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1020605112755

1 reference

PubMed ID

9699918

Dimensions Publication ID

11 December 2017

0 references

1 reference

PubMed ID

9699918