(Q45297081)

11 December 2017

title

Phenytoin teratogenicity: hypoxia marker and effects on embryonic heart rhythm suggest an hERG-related mechanism (English)

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11 December 2017

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ChEBI release 2020-05-28

Bengt R Danielsson

1

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11 December 2017

Alf Johansson

2

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11 December 2017

Christian Danielsson

3

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11 December 2017

Faranak Azarbayjani

4

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11 December 2017

Bo Blomgren

5

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11 December 2017

Anna-Carin Sköld

6

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11 December 2017

publication date

1 March 2005

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Birth Defects Research Part A: Clinical and Molecular Teratology

11 December 2017

published in

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11 December 2017

volume

73

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11 December 2017

issue

3

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11 December 2017

page(s)

146-153

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Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage

11 December 2017

cites work

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https://api.crossref.org/works/10.1002%2FBDRA.20124

Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?

21 January 2018

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Computer-assisted quantification and image processing of whole-body autoradiograms.

21 January 2018

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Pharmacokinetic data support pharmacologically induced embryonic dysrhythmia as explanation to Fetal Hydantoin Syndrome in rats.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBDRA.20124

Phenytoin and phenobarbital inhibit human HERG potassium channels

21 January 2018

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https://api.crossref.org/works/10.1002%2FBDRA.20124

Teratogenicity by the hERG potassium channel blocking drug almokalant: use of hypoxia marker gives evidence for a hypoxia-related mechanism mediated via embryonic arrhythmia

21 January 2018

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https://api.crossref.org/works/10.1002%2FBDRA.20124

Parental epilepsy, anticonvulsant drugs, and reproductive outcome: epidemiologic and experimental findings spanning three decades; 2: Human studies

21 January 2018

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Reactive oxygen species in developmental toxicity: review and hypothesis

21 January 2018

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https://api.crossref.org/works/10.1002%2FBDRA.20124

Parental epilepsy, anticonvulsant drugs, and reproductive outcome: epidemiologic and experimental findings spanning three decades; 1: Animal studies

21 January 2018

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https://api.crossref.org/works/10.1002%2FBDRA.20124

The teratogenicity of anticonvulsant drugs

21 January 2018

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https://api.crossref.org/works/10.1002%2FBDRA.20124

Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia

21 January 2018

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https://api.crossref.org/works/10.1002%2FBDRA.20124

Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development

21 January 2018

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Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism?

21 January 2018

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Limb deficiencies in newborn infants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20124

Hypothermia and phenytoin toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20124

Craniofacial skeletal deviations following in utero exposure to the anticonvulsant phenytoin: monotherapy and polytherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20124

The importance of monotherapy in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20124

Teratogenicity of the I(Kr)-blocker cisapride: relation to embryonic cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20124

Teratogenic potential of almokalant, dofetilide, and d-sotalol: drugs with potassium channel blocking activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20124

Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20124

21 January 2018

Identifiers

DOI

10.1002/BDRA.20124

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11 December 2017

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