(Q45298950)

11 December 2017

title

CYTE-I-HD: phase I dose finding and tolerability study of cysteamine (Cystagon) in Huntington's disease (English)

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11 December 2017

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1

Richard Dubinsky

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11 December 2017

Carolyn Gray

2

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11 December 2017

language of work or name

English

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publication date

1 April 2006

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11 December 2017

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11 December 2017

volume

21

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11 December 2017

issue

4

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11 December 2017

page(s)

530-533

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

11 December 2017

cites work

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Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

21 January 2018

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

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Cross linking of polyglutamine domains catalyzed by tissue transglutaminase is greatly favored with pathological-length repeats: does transglutaminase activity play a role in (CAG)(n)/Q(n)-expansion diseases?

21 January 2018

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Evidence for a role for transglutaminase in Huntington's disease and the potential therapeutic implications

21 January 2018

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Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei

21 January 2018

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Differential expression of multiple transglutaminases in human brain. Increased expression and cross-linking by transglutaminases 1 and 2 in Alzheimer's disease

21 January 2018

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Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.

21 January 2018

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21 January 2018

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The rational clinical examination. Is this patient malnourished?

21 January 2018

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Long-term effects of cysteamine on cognitive and locomotor behavior in rats: relationship to hippocampal glial pathology and somatostatin levels.

21 January 2018

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Cysteamine-induced depletion of central somatostatin-like immunoactivity: effects on behavior, learning, memory and brain neurochemistry

21 January 2018

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Intrahippocampal injections of cysteamine improve the retention of a bar-pressing task in mice

21 January 2018

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Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease

21 January 2018

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Unified Huntington's disease rating scale: Reliability and consistency

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MDS.20756

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11 December 2017

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