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English
Stochastic kinetics of intracellular huntingtin aggregate formation.
scientific article published on 14 May 2006
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Europe PubMed Central
PubMed publication ID
16699519
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
title
Stochastic kinetics of intracellular huntingtin aggregate formation
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16699519
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
author
David W Colby
series ordinal
1
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Europe PubMed Central
PubMed publication ID
16699519
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
author name string
John P Cassady
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2
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Europe PubMed Central
PubMed publication ID
16699519
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
Grace C Lin
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3
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Europe PubMed Central
PubMed publication ID
16699519
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
Vernon M Ingram
series ordinal
4
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PubMed publication ID
16699519
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21 January 2020
K Dane Wittrup
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5
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Europe PubMed Central
PubMed publication ID
16699519
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
publication date
14 May 2006
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16699519
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
published in
Nature Chemical Biology
1 reference
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Europe PubMed Central
PubMed publication ID
16699519
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
volume
2
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Europe PubMed Central
PubMed publication ID
16699519
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retrieved
21 January 2020
issue
6
1 reference
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Europe PubMed Central
PubMed publication ID
16699519
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
page(s)
319-323
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16699519
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
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Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats
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Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation
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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
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7 January 2021
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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
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Impairment of the ubiquitin-proteasome system by protein aggregation
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Expanded huntingtin activates the c-Jun terminal kinase/c-Jun pathway prior to aggregate formation in striatal neurons in culture.
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Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1
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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.
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Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
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Kinetics and Mechanism of Deoxyhemoglobin S Gelation: A New Approach to Understanding Sickle Cell Disease
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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?
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Generation and characterization of embryonic striatal conditionally immortalized ST14A cells
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Fluctuations in the polymerization of sickle hemoglobin. A simple analytic model.
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polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction
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Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease?
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Macromolecular crowding accelerates amyloid formation by human apolipoprotein C-II.
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Nonideality and the nucleation of sickle hemoglobin
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The influence of macromolecular crowding and macromolecular confinement on biochemical reactions in physiological media
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Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions
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7 January 2021
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Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
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A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo
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A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila
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Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody
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Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.
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RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model
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Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
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Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course
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Identifiers
DOI
10.1038/NCHEMBIO792
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16699519
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
Dimensions Publication ID
1008417893
0 references
PubMed publication ID
16699519
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16699519
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16699519%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 January 2020
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