(Q45302322)

11 December 2017

Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin (English)

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11 December 2017

Jennifer L Illuzzi

1

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11 December 2017

Cassie A Vickers

series ordinal

2

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11 December 2017

Eric B Kmiec

series ordinal

3

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11 December 2017

5 April 2011

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Journal of Molecular Neuroscience

11 December 2017

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11 December 2017

45

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11 December 2017

2

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11 December 2017

256-268

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https://scigraph.springernature.com/pub.10.1007/s12031-011-9516-4

11 December 2017

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cites work

The Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Modifications of p53: competing for the lysines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Mutant huntingtin represses CBP, but not p300, by binding and protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

p53 and MDM2: antagonists or partners in crime?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Mutant huntingtin impairs Ku70-mediated DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Huntington's disease: a clinical, genetic and molecular model for polyglutamine repeat disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

p53 Oligomerization is essential for its C-terminal lysine acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Identification of p53 as a sequence-specific DNA-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Interaction of Huntington disease protein with transcriptional activator Sp1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

p53 regulates hematopoietic stem cell quiescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Monoubiquitylation promotes mitochondrial p53 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

p53 suppresses the self-renewal of adult neural stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Sequence-specific transcriptional activation is essential for growth suppression by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Identification of the full-length huntingtin- interacting protein p231HBP/HYPB as a DNA-binding factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

SUMO modification of Huntingtin and Huntington's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

The cellular response to p53: the decision between life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

p53 in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-011-9516-4

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

21 January 2018

1 reference

12 December 2020

Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease

1 reference

12 December 2020

p53 tumor suppressor protein regulates the levels of huntingtin gene expression

1 reference

12 December 2020

The expanding universe of p53 targets

1 reference

12 December 2020

1 reference

12 December 2020

10.1007/S12031-011-9516-4

Identifiers

DOI

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Dimensions Publication ID

11 December 2017

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