(Q45303178)

11 December 2017

Discovery of Small Molecules that Induce the Degradation of Huntingtin (English)

1 reference

11 December 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28703441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Kenji Ohgane

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28703441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Minoru Ishikawa

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28703441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Sayaka Nomura

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28703441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Yuichi Hashimoto

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28703441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

language of work or name

English

0 references

publication date

13 July 2017

1 reference

Angewandte Chemie International Edition

11 December 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28703441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

56

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28703441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28703441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

11530-11533

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28703441%20AND%20SRC:MED&resulttype=core&format=json

Genetics and neuropathology of Huntington's disease

4 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

siRNA screen identifies QPCT as a druggable target for Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Investigational agents for the management of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Hybrid molecules with a dual mode of action: dream or reality?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Induced protein degradation: an emerging drug discovery paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Small-Molecule PROTACS: New Approaches to Protein Degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Development of target protein-selective degradation inducer for protein knockdown.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

(18)F-labeled phenyldiazenyl benzothiazole for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Small molecules destabilize cIAP1 by activating auto-ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Toxicity of expanded polyglutamine-domain proteins in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Huntington's disease: a clinical, genetic and molecular model for polyglutamine repeat disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

Formation and toxicity of soluble polyglutamine oligomers in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201706529

21 January 2018

Identifiers

DOI

10.1002/ANIE.201706529

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28703441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference