(Q45316808)

English

RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8936459)

In more languages

edit

Statements

1 reference

8 July 2022

regulation of megakaryocyte differentiation

1 reference

8 July 2022

Transcriptional regulation by RUNX1

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-8936459

1 reference

8 July 2022

1 reference

8 July 2022

PRMT1 arginine-methylates RUNX1

1 reference

8 July 2022

RUNX1 binds SIN3A,(SIN3B) co-repressor

1 reference

8 July 2022

RUNX1 and GATA1 bind the promoter of the ITGA2B gene

1 reference

8 July 2022

Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter

1 reference

8 July 2022

RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter

1 reference

8 July 2022

ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6

1 reference

8 July 2022

PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter

1 reference

8 July 2022

RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter

1 reference

8 July 2022

PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter

1 reference

8 July 2022

RUNX1 and GATA1 bind the promoter of the GP1BA gene

1 reference

8 July 2022

Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter

1 reference

8 July 2022

GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6

1 reference

8 July 2022

RUNX1 and GATA1 bind the promoter of the THBS1 gene

1 reference

8 July 2022

Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter

1 reference

8 July 2022

RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter

1 reference

8 July 2022

PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter

1 reference

8 July 2022

THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6

1 reference

8 July 2022

RUNX1 and GATA1 bind the promoter of the MIR27A gene

1 reference

8 July 2022

Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter

1 reference

8 July 2022

RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter

1 reference

8 July 2022

PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter

1 reference

8 July 2022

MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6

1 reference

8 July 2022

RUNX1:CBFB binds the NR4A3 gene promoter

1 reference

8 July 2022

PF4 gene transcription is stimulated by RUNX1:CBFB

1 reference

8 July 2022

RUNX1:CBFB binds the PF4 gene promoter

1 reference

8 July 2022

NR4A3 gene expression is stimulated by RUNX1:CBFB

1 reference

8 July 2022

RUNX1:CBFB binds the PRKCQ gene promoter

1 reference

8 July 2022

PRKCQ gene expression is stimulated by RUNX1:CBFB

1 reference

8 July 2022

RUNX1:CBFB binds the MYL9 gene promoter

1 reference

8 July 2022

MYL9 gene transcription is stimulated by RUNX1:CBFB

1 reference

8 July 2022

RUNX1:CBFB binds the NFE2 gene promoter

1 reference

8 July 2022

NFE2 gene expression is stimulated by RUNX1:CBFB

1 reference

8 July 2022

Histone arginine methylation keeps RUNX1 target genes in an intermediate state

1 reference

8 July 2022

Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency

1 reference

8 July 2022

AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2

1 reference

8 July 2022

A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis

1 reference

8 July 2022

Thrombospondin-1 in von Willebrand factor function

1 reference

8 July 2022

Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome

1 reference

8 July 2022

Platelet glycoprotein IIb gene expression as a model of megakaryocyte-specific expression

1 reference

8 July 2022

RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation

1 reference

8 July 2022

Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1.

1 reference

8 July 2022

Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4.

1 reference

8 July 2022

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

1 reference

8 July 2022

Structural determinants within platelet glycoprotein Ibalpha involved in its binding to von Willebrand factor.

1 reference

8 July 2022

Expression of platelet glycoprotein Ib by cultured human megakaryocytes: ultrastructural localization and biosynthesis

1 reference

8 July 2022

Glycoprotein Ib polymorphisms influence platelet plug formation under high shear rates

1 reference

8 July 2022

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q45316808)

RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)