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GAB1 signalosome
An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-180292)
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Statements
instance of
biological pathway
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
part of
Signaling by EGFR
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
exact match
https://identifiers.org/reactome:R-HSA-180292
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
has part(s)
Binding of GRB2 to GAB1
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
GRB2:GAB1 binds to phosphorylated EGFR
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
PI3K binds to EGF:EGFR:GRB2:GAB1
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
GAB1 phosphorylation by EGFR kinase
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
Dephosphorylation of Gab1 by SHP2
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
Activation of SHP2 through the binding to phospho-Gab1
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
Dephosphorylation of PAG by SHP2
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
SHP2 dephosphorylates Tyr 992 on EGFR
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
Sustained activation of SRC kinase by SHP2
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
cites work
The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
Identifiers
Reactome ID
R-HSA-180292
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-180292
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