(Q50297482)

English

Activation of SHP2 through the binding to phospho-Gab1

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-177944)

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Statements

biological process

1 reference

8 July 2022

GAB1 signalosome

1 reference

13 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-177944

1 reference

8 July 2022

EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]

1

object has role

1 reference

8 July 2022

Protein tyrosine phosphatase non-receptor type 11

1

object has role

1 reference

8 July 2022

EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]

1

object has role

1 reference

8 July 2022

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

1 reference

8 July 2022

Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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