(Q45318311)

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RHO GTPases activate PAKs

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5627123)

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https://identifiers.org/reactome:R-HSA-5627123

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MYLK (MLCK) Active Calmodulin Binding

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RAC1 and CDC42 activate PAK1

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PAK1 phosphorylates LIMK1

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Autophosphorylation of PAK1,2,3

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Myosin phosphatase dephosphorylates myosin regulatory light chain

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RAC1 and CDC42 activate PAK2

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RAC1 and CDC42 activate PAK3

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PAK2 phosphorylates myosin regulatory light chain (MRLC)

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PAK1 phosphorylates myosin phosphatase

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MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex

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PAK1 or PAK2 phosphorylates MYLK

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PAK phosphorylates cortactin

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PAK1 phosphorylates FLNA

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PAKs in human disease

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

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Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA

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8 July 2022

Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification

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8 July 2022

p21-activated protein kinase: a crucial component of morphological signaling?

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Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements

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Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

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8 July 2022

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

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8 July 2022

Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family

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8 July 2022

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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8 July 2022

Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141.

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8 July 2022

Identifiers

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8 July 2022

(Q45318311)

RHO GTPases activate PAKs

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