Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q28609687)
Watch
English
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1
scientific journal article
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
title
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1
(English)
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
main subject
autoinhibition
0 references
author
Stephen C. Harrison
series ordinal
3
object named as
Stephen C. Harrison
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
author name string
Maria Carla Parrini
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
Ming Lei
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
Bruce J. Mayer
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
publication date
1 January 2002
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
published in
Molecular Cell
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
volume
9
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
issue
1
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
page(s)
73–83
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
cites work
A novel regulator of p21-activated kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rho GTPases and their effector proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conformational switch and role of phosphorylation in PAK activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Ste20 group kinases as regulators of MAP kinase cascades
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leucine zipper-mediated homodimerization of the p21-activated kinase-interacting factor, beta Pix. Implication for a role in cytoskeletal reorganization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p21Rac/Cdc42-activated kinases (PAKs).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of Cdc42 bound to the GTPase binding domain of PAK
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the Nef-associated kinase as p21-activated kinase 2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Akt proto-oncogene links Ras to Pak and cell survival signals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Delineation of the Cdc42/Rac-binding domain of p21-activated kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900428-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1097-2765(01)00428-2
0 references
PubMed ID
11804587
1 reference
stated in
PubMed
PubMed ID
11804587
retrieved
3 February 2017
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit