(Q45345885)

13 December 2017

title

Patching the gaps in Hedgehog signalling (English)

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13 December 2017

Rajat Rohatgi

1

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13 December 2017

Matthew P Scott

series ordinal

2

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13 December 2017

publication date

1 September 2007

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13 December 2017

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13 December 2017

volume

9

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13 December 2017

issue

9

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13 December 2017

page(s)

1005-1009

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Hedgehog signaling in animal development: paradigms and principles

13 December 2017

cites work

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Shifting paradigms in Hedgehog signaling

21 January 2018

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Hedgehog signaling and human disease

21 January 2018

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Tissue repair and stem cell renewal in carcinogenesis

21 January 2018

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

21 January 2018

1 reference

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

21 January 2018

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Communicating with Hedgehogs

21 January 2018

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

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Small molecule modulation of Smoothened activity

21 January 2018

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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

21 January 2018

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

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Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

21 January 2018

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Teratogen-mediated inhibition of target tissue response to Shh signaling

21 January 2018

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A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

21 January 2018

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Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

21 January 2018

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Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells

21 January 2018

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Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

21 January 2018

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Patched acts catalytically to suppress the activity of Smoothened

21 January 2018

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

21 January 2018

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Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.

21 January 2018

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Transmembrane molecular pump activity of Niemann-Pick C1 protein

21 January 2018

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Crystal structure of bacterial multidrug efflux transporter AcrB

21 January 2018

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Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein.

21 January 2018

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The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover

21 January 2018

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Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

21 January 2018

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The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

21 January 2018

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Sonic hedgehog induces the segregation of patched and smoothened in endosomes

21 January 2018

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Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

21 January 2018

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Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila

21 January 2018

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The sterol-sensing domain: multiple families, a unique role?

21 January 2018

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Hedgehog signalling in the mouse requires intraflagellar transport proteins

21 January 2018

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Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

21 January 2018

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21 January 2018

Intraflagellar transport

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Vertebrate Smoothened functions at the primary cilium

21 January 2018

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

21 January 2018

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Cilia and Hedgehog responsiveness in the mouse

21 January 2018

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Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

21 January 2018

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A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

21 January 2018

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Patched1 regulates hedgehog signaling at the primary cilium

21 January 2018

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Protein sensors for membrane sterols

21 January 2018

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Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

21 January 2018

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Structures of Biologically Active Oxysterols Determine Their Differential Effects on Phospholipid Membranes†

21 January 2018

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21 January 2018

Mending and malignancy

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Targeting the Hedgehog pathway in cancer

21 January 2018

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7 January 2021

The cell biology of Smo signalling and its relationships with GPCRs

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7 January 2021

Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes

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7 January 2021

PTCH mutations: distribution and analyses

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7 January 2021

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

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7 January 2021

Identifiers

DOI

10.1038/NCB435

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Dimensions Publication ID

13 December 2017

1043349302

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