(Q45348533)

13 December 2017

title

Predicting drug candidate victims of drug-drug interactions, using microdosing (English)

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13 December 2017

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Brendan Keely

2

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author name string

Marie Croft

1

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13 December 2017

Ian Morris

3

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13 December 2017

Lan Tann

4

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13 December 2017

Graham Lappin

5

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13 December 2017

publication date

1 April 2012

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Clinical Pharmacokinetics

13 December 2017

published in

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13 December 2017

volume

51

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13 December 2017

issue

4

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13 December 2017

page(s)

237-246

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https://scigraph.springernature.com/pub.10.2165/11597070-000000000-00000

13 December 2017

exact match

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cites work

Microdosing: a valuable tool for accelerating drug development and the role of bioanalytical methods in meeting the challenge

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Microdosing: current and the future

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Trends in microdosing and other exploratory human pharmacokinetic studies for early drug development.

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Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause qt prolongation

21 January 2018

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Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies

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Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability

21 January 2018

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Use of microdosing to predict pharmacokinetics at the therapeutic dose: experience with 5 drugs.

21 January 2018

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21 January 2018

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21 January 2018

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Effect of oral ketoconazole on intestinal first-pass effect of midazolam and fexofenadine in cynomolgus monkeys

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AMS method validation for quantitation in pharmacokinetic studies with concomitant extravascular and intravenous administration

21 January 2018

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21 January 2018

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Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics

21 January 2018

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Dose proportionality and comparison of single and multiple dose pharmacokinetics of fexofenadine (MDL 16455) and its enantiomers in healthy male volunteers

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Some pharmacokinetic aspects of the lipophilic terfenadine and zwitterionic fexofenadine in humans

21 January 2018

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21 January 2018

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Microdosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit juice) profiles of celiprolol following the oral microdose and therapeutic dose

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12 December 2020

A comprehensive analysis of the role of correction factors in the allometric predictivity of clearance from rat, dog, and monkey to humans

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12 December 2020

Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry

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12 December 2020

Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches

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12 December 2020

Accelerator mass spectrometry as a bioanalytical tool for nutritional research

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12 December 2020

Intestinal and Hepatic Metabolic Activity of Five Cytochrome P450 Enzymes: Impact on Prediction of First-Pass Metabolism

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12 December 2020

Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

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12 December 2020

Microdose clinical trial: quantitative determination of fexofenadine in human plasma using liquid chromatography/electrospray ionization tandem mass spectrometry

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12 December 2020

Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity

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12 December 2020

Influence of cytochrom P450 CYP2C9 polymorphism on the pharmacokinetics of tolbutamide metabolism using oligonucleotide genotyping microarray

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12 December 2020

10.2165/11597070-000000000-00000

Identifiers

DOI

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Dimensions Publication ID

13 December 2017

1012906746

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1 reference