(Q45352054)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

The effect of dichloroacetate on health- and lifespan in C. elegans (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

main subject

dichloroacetate

0 references

Caenorhabditis elegans

0 references

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

S Schaffer

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

J Gruber

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

L F Ng

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Y T Wong

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

S Y Tang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

B Halliwell

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

publication date

14 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

195-209

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21153705%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s10522-010-9310-7

18 January 2020

exact match

0 references

cites work

Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Number matters: control of mammalian mitochondrial DNA copy number

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

The metabolic effects of dichloroacetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Effect of colour of drugs: systematic review of perceived effect of drugs and of their effectiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Cells discover fire: employing reactive oxygen species in development and consequences for aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

The evolution of mammalian aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Can we intervene in human ageing?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Slow mortality rate accelerations during aging in some animals approximate that of humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Changing course in ageing research: The healthy ageing phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

A simple method for maintaining large, aging populations of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Insulin/IGF signalling and ageing: seeing the bigger picture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

The mitochondrial free radical theory of ageing--where do we stand?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Deceptively simple but simply deceptive--Caenorhabditis elegans lifespan studies: considerations for aging and antioxidant effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Caenorhabditis elegans life span studies: the challenge of maintaining synchronous cohorts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Aging: a theory based on free radical and radiation chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Markers of protein oxidation: different oxidants give rise to variable yields of bound and released carbonyl products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Quantitative lipid analysis and life span of the fat-3 mutant of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Metabolic networks of longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

On the importance of fatty acid composition of membranes for aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Ill or just old? Towards a conceptual framework of the relation between ageing and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Development of fluorescence between o-phthaldialdehyde and thiols

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Effect of dichloroacetate on regional energy metabolites and pyruvate dehydrogenase activity during ischemia and reperfusion in gerbil brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

21 January 2018

The genetics of ageing

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Mitochondrial function as a determinant of life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Genetic contribution to aging: deleterious and helpful genes define life expectancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

When a theory of aging ages badly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Signaling by ROS drives inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

AlphaMUPA mice: a transgenic model for longevity induced by caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

How mitochondria produce reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Platelet mitochondrial evaluation during cytochrome c and dichloroacetate treatments of MELAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Using Caenorhabditis elegans as a model for aging and age-related diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Mitochondria and ageing: winning and losing in the numbers game.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Why do life spans differ? Partitioning mean longevity differences in terms of age-specific mortality parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Stochastic drift in mitochondrial DNA point mutations: a novel perspective ex silico

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

The ageing epigenome: damaged beyond repair?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Mechanisms of aging: an appraisal of the oxidative stress hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

The pharmacology of dichloroacetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Mitochondrial formation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Fat metabolism links germline stem cells and longevity in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Counting target molecules by exponential polymerase chain reaction: copy number of mitochondrial DNA in rat tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Visualizing hidden heterogeneity in isogenic populations of C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Dichloroacetate: Effects on exercise endurance in untrained rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7

Benchmarks for ageing studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-010-9310-7