(Q45411954)

14 December 2017

title

Engineered herpes simplex virus expressing bacterial cytosine deaminase for experimental therapy of brain tumors (English)

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14 December 2017

M B Guffey

1

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14 December 2017

J N Parker

2

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14 December 2017

W S Luckett

3

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14 December 2017

G Y Gillespie

4

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14 December 2017

S Meleth

5

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14 December 2017

R J Whitley

6

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14 December 2017

J M Markert

7

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14 December 2017

publication date

22 September 2006

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14 December 2017

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14 December 2017

volume

14

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14 December 2017

issue

1

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14 December 2017

page(s)

45-56

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https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700978

14 December 2017

exact match

0 references

cites work

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The herpes simplex virus type 2 (HG52) variant JH2604 has a 1488 bp deletion which eliminates neurovirulence in mice

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Herpes simplex virus neurovirulence and productive infection of neural cells is associated with a function which maps between 0.82 and 0.832 map units on the HSV genome

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Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

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Treatment of human breast cancer in a brain metastatic model by G207, a replication-competent multimutated herpes simplex virus 1.

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Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma

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Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins

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Engineered herpes simplex virus expressing IL-12 in the treatment of experimental murine brain tumors

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Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

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Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial

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A generalized technique for deletion of specific genes in large genomes: alpha gene 22 of herpes simplex virus 1 is not essential for growth.

21 January 2018

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Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system

21 January 2018

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Enhanced inhibition of syngeneic murine tumors by combinatorial therapy with genetically engineered HSV-1 expressing CCL2 and IL-12.

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Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma model

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The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D

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Complex interactions between the replicating oncolytic effect and the enzyme/prodrug effect of vaccinia-mediated tumor regression

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Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model

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Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes

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Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization

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Interleukin 12 secretion enhances antitumor efficacy of oncolytic herpes simplex viral therapy for colorectal cancer

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7 January 2021

Naked DNA gene delivery to the liver

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700978

7 January 2021

The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700978

7 January 2021

Pyrimidine, purine and nitrogen control of cytosine deaminase synthesis in Escherichia coli K 12. Involvement of the glnLG and purR genes in the regulation of codA expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700978

7 January 2021

Neuroblastoma grafts are noninvasively removed within mouse neocortex by selective laser activation of intracellular photolytic chromophore

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700978

7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700978

1 reference

Dimensions Publication ID

14 December 2017

1027501180

0 references

1 reference