(Q45713868)

15 December 2017

title

A novel gain-of-function mutation of the integrin alpha2 VWFA domain (English)

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15 December 2017

4

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15 December 2017

Alexis Aquilina

1

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15 December 2017

Michelle Korda

2

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15 December 2017

Jeffrey M Bergelson

3

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15 December 2017

Richard W Farndale

5

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15 December 2017

Danny Tuckwell

6

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15 December 2017

language of work or name

English

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publication date

1 February 2002

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15 December 2017

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15 December 2017

volume

269

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15 December 2017

issue

4

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15 December 2017

page(s)

1136-1144

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Ligand recognition by the I domain-containing integrins

15 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

The collagen receptor integrins have distinct ligand recognition and signaling functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a functionally important region within alpha2beta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

alpha 2beta 1 integrin is not recognized by rhodocytin but is the specific, high affinity target of rhodocetin, an RGD-independent disintegrin and potent inhibitor of cell adhesion to collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

There is binding of collagen IV to beta 1 integrin during early skin basement membrane assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Association of two silent polymorphisms of platelet glycoprotein Ia/IIa receptor with risk of myocardial infarction: a case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Regulation of inflammation by collagen-binding integrins alpha1beta1 and alpha2beta1 in models of hypersensitivity and arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Identification in collagen type I of an integrin alpha2 beta1-binding site containing an essential GER sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Crystal structure of the I domain from integrin alpha2beta1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Structural basis of collagen recognition by integrin alpha2beta1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Two functional states of the CD11b A-domain: correlations with key features of two Mn2+-complexed crystal structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Computational design of an integrin I domain stabilized in the open high affinity conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Characterization of a type IV collagen major cell binding site with affinity to the alpha 1 beta 1 and the alpha 2 beta 1 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Rapid and efficient site-specific mutagenesis without phenotypic selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

An immunological analysis of Ty1 virus-like particle structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Echovirus 1 interaction with the human very late antigen-2 (integrin alpha2beta1) I domain. Identification of two independent virus contact sites distinct from the metal ion-dependent adhesion site

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Identification of a binding site for integrin alphaEbeta7 in the N-terminal domain of E-cadherin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Integrin–collagen binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Molecular Characterisation of Integrin-Procollagen C-Propeptide Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

The A-Domain of Integrin alpha2 Binds Specifically to a Range of Collagens but is not a General Receptor for the Collagenous Motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

The Integrin α1 A-domain Is a Ligand Binding Site for Collagens and Laminin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Identification of the integrin VLA-2 as a receptor for echovirus 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Effect of gel re-organization and tensional forces on alpha2beta1 integrin levels in dermal fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

Polymorphisms of the human platelet antigens HPA-1, HPA-2, HPA-3, and HPA-5 on the platelet receptors for fibrinogen (GPIIb/IIIa), von Willebrand factor (GPIb/IX), and collagen (GPIa/IIa) are not correlated with an increased risk for stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

The GPIa C807T dimorphism associated with platelet collagen receptor density is not a risk factor for myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02740.X

10.1046/J.0014-2956.2001.02740.X

21 January 2018

Identifiers

DOI

1 reference

15 December 2017

1 reference