(Q45733258)

English

Insertion of interleukin-2 (IL-2) and interleukin-12 (IL-12) genes into vaccinia virus results in effective anti-tumor responses without toxicity

scientific article published in March 2002

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scholarly article

1 reference

Europe PubMed Central

15 December 2017

Insertion of interleukin-2 (IL-2) and interleukin-12 (IL-12) genes into vaccinia virus results in effective anti-tumor responses without toxicity (English)

1 reference

Europe PubMed Central

15 December 2017

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object named as

vaccinia virus

1 reference

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author name string

Howard L Kaufman

1

1 reference

Europe PubMed Central

15 December 2017

Ken Flanagan

2

1 reference

Europe PubMed Central

15 December 2017

Christopher S D Lee

3

1 reference

Europe PubMed Central

15 December 2017

Donato J Perretta

4

1 reference

Europe PubMed Central

15 December 2017

Heidi Horig

5

1 reference

Europe PubMed Central

15 December 2017

language of work or name

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publication date

1 March 2002

1 reference

Europe PubMed Central

15 December 2017

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Europe PubMed Central

15 December 2017

20

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Europe PubMed Central

15 December 2017

13-14

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Europe PubMed Central

15 December 2017

1862-1869

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Europe PubMed Central

15 December 2017

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection

1 reference

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7 January 2021

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Tumor antigens recognized by T cells

1 reference

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Results of a phase I trial of a recombinant vaccinia virus that expresses carcinoembryonic antigen in patients with advanced colorectal cancer

1 reference

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Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: persistent transgene expression despite antibody generation.

1 reference

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Phase I study in advanced cancer patients of a diversified prime-and-boost vaccination protocol using recombinant vaccinia virus and recombinant nonreplicating avipox virus to elicit anti-carcinoembryonic antigen immune responses

1 reference

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Cytokine gene therapy or infusion as treatment for solid human cancer.

1 reference

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Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine

1 reference

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Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-gamma).

1 reference

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IL-12 stimulation but not B7 expression increases melanoma killing by patient cytotoxic T lymphocytes (CTL)

1 reference

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Organization and structure of the mouse interleukin-2 gene

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Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells

1 reference

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Cloning and structure of a mouse interleukin-2 chromosomal gene

1 reference

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Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report

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Tumour-infiltrating lymphocytes and interleukin-2 in treatment of advanced cancer

1 reference

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High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993

1 reference

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Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype

1 reference

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Expression of cytokines by recombinant vaccinia viruses: a model for studying cytokines in virus infections in vivo

1 reference

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Immunomodulation by Quillaja saponaria adjuvant formulations: in vivo stimulation of interleukin 12 and its effects on the antibody response

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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

1 reference

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Antitumor and antimetastatic activity of interleukin 12 against murine tumors

1 reference

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7 January 2021

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inferred from DOI database lookup

Administration of systemic or local interleukin-2 enhances the anti-tumor effects of interleukin-12 gene therapy

1 reference

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7 January 2021

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New vaccinia virus recombination plasmids incorporating a synthetic late promoter for high level expression of foreign proteins

1 reference

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7 January 2021

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Cytokine production and antitumor effect of a nonreplicating, noncytopathic recombinant vaccinia virus expressing interleukin-12.

1 reference

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7 January 2021

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Administration of interleukin 12 with pulse interleukin 2 and the rapid and complete eradication of murine renal carcinoma

1 reference

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Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: induction of local T cell infiltration, Fas/Fas ligand gene expression, and mammary

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2802%2900032-4

7 January 2021

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inferred from DOI database lookup

IFN-gamma and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2802%2900032-4

7 January 2021

based on heuristic

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Combination interleukin-2 and interleukin-12 induces severe gastrointestinal toxicity and epithelial cell apoptosis in mice

1 reference

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Colon cancer cell vaccine prepared with replication-deficient vaccinia viruses encoding B7.1 and interleukin-2 induce antitumor response in syngeneic mice.

1 reference

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7 January 2021

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Identifiers

10.1016/S0264-410X(02)00032-4

1 reference

Europe PubMed Central

15 December 2017

1 reference

Europe PubMed Central

15 December 2017

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