(Q45735200)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23774673%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts (English)

1 reference

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3 March 2020

1 reference

1 reference

1 reference

lymphoblastic leukemia

1 reference

4

1 reference

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3 March 2020

Stefano Indraccolo

14

1 reference

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3 March 2020

Valentina Agnusdei

1

1 reference

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3 March 2020

Giuseppe Basso

10

1 reference

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3 March 2020

Silvia Valtorta

11

1 reference

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3 March 2020

author name string

S Minuzzo

2

1 reference

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3 March 2020

C Frasson

3

1 reference

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3 March 2020

F Axelrod

5

1 reference

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3 March 2020

S Satyal

6

1 reference

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3 March 2020

A Gurney

7

1 reference

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3 March 2020

T Hoey

8

1 reference

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3 March 2020

E Seganfreddo

9

1 reference

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3 March 2020

R M Moresco

12

1 reference

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3 March 2020

A Amadori

13

1 reference

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3 March 2020

publication date

18 June 2013

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3 March 2020

1 reference

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3 March 2020

volume

28

1 reference

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3 March 2020

issue

2

1 reference

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3 March 2020

page(s)

278-288

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https://scigraph.springernature.com/pub.10.1038/leu.2013.183

3 March 2020

exact match

0 references

cites work

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

1 reference

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Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines

21 January 2018

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

21 January 2018

1 reference

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Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

21 January 2018

1 reference

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

21 January 2018

1 reference

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Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

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1 reference

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Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

21 January 2018

1 reference

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Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease

21 January 2018

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Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors

21 January 2018

1 reference

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Therapeutic antibody targeting of individual Notch receptors

21 January 2018

1 reference

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The canonical Notch signaling pathway: unfolding the activation mechanism

21 January 2018

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Notch signaling in leukemia

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Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance.

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NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches

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A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

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Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.

21 January 2018

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21 January 2018

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The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

21 January 2018

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Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer

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CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

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NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia.

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Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

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21 January 2018

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21 January 2018

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Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

21 January 2018

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12 December 2020

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12 December 2020

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12 December 2020

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