(Q45752028)

15 December 2017

review article

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title

Anti-human immunodeficiency virus drug combination strategies (English)

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15 December 2017

author

Anne-Mieke Vandamme

series ordinal

1

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15 December 2017

author name string

K Van Vaerenbergh

series ordinal

2

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15 December 2017

E De Clercq

series ordinal

3

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15 December 2017

publication date

1 May 1998

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15 December 2017

Antiviral Chemistry & Chemotherapy

published in

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15 December 2017

volume

9

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15 December 2017

issue

3

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15 December 2017

page(s)

187-203

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15 December 2017

Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors

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A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors

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Targeting of HIV- and SIV-infected cells by CD4-chemokine receptor pseudotypes

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Human immunodeficiency virus (HIV) RNA in plasma as the preferred target for therapy in patients with HIV infection: a critique

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The effects on survival of early treatment of human immunodeficiency virus infection

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Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy

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High-dose nevirapine: safety, pharmacokinetics, and antiviral effect in patients with human immunodeficiency virus infection

21 January 2018

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Viral dynamics of HIV: implications for drug development and therapeutic strategies

21 January 2018

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A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs

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A microtitre format point mutation assay: application to the detection of drug resistance in human immunodeficiency virus type-1 infected patients treated with zidovudine

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Recombinant virus assay: a rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates.

21 January 2018

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A controlled trial of zidovudine in primary human immunodeficiency virus infection

21 January 2018

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2',3'-dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. A phase I trial

21 January 2018

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3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

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21 January 2018

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Safety and tolerance of dideoxycytidine as a single agent. Results of early-phase studies in patients with acquired immunodeficiency syndrome (AIDS) or advanced AIDS-related complex. Study Group of the AIDS Clinical Trials Group of the National Inst

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21 January 2018

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21 January 2018

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21 January 2018

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Ordered accumulation of mutations in HIV protease confers resistance to ritonavir

21 January 2018

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Clonal selection of HIV type 1 variants associated with resistance to foscarnet in vitro: confirmation by molecular evolutionary analysis.

21 January 2018

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Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

21 January 2018

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Lamivudine-resistant human immunodeficiency virus type 1 variants (184V) require multiple amino acid changes to become co-resistant to zidovudine in vivo

21 January 2018

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HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

21 January 2018

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Decay characteristics of HIV-1-infected compartments during combination therapy

21 January 2018

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Zidovudine phosphorylation after short-term and long-term therapy with zidovudine in patients infected with the human immunodeficiency virus

21 January 2018

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A phase I/II study of 2'-deoxy-3'-thiacytidine (lamivudine) in patients with advanced human immunodeficiency virus infection

21 January 2018

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The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

21 January 2018

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21 January 2018

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21 January 2018

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The effect of high-dose saquinavir on viral load and CD4+ T-cell counts in HIV-infected patients.

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632029800900301

Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632029800900301

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632029800900301

Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants

21 January 2018

1 reference

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Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

21 January 2018

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Mother to child transmission of zidovudine-resistant HIV-1.

21 January 2018

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21 January 2018

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Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Activity of tethered human immunodeficiency virus 1 protease containing mutations in the flap region of one subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632029800900301

Characterization of HIV-1 strains isolated from patients treated with TIBO R82913.

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632029800900301

Treatment dilemmas in HIV infection

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632029800900301

Identification, purification, and cell culture assays of retroviral proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Viral dynamics in human immunodeficiency virus type 1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Zidovudine. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Escape mutants of HIV-1 proteinase: enzymic efficiency and susceptibility to inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Human immunodeficiency virus type-1 reverse transcriptase. Contribution of Met-184 to binding of nucleoside 5'-triphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

Natural occurrence of drug resistance mutations in the reverse transcriptase of human immunodeficiency virus type 1 isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632029800900301

10.1177/095632029800900301

21 January 2018

Identifiers

DOI

1 reference

15 December 2017

PubMed ID

9875399

1 reference

15 December 2017