(Q45759945)

15 December 2017

title

Mutations in MexB that affect the efflux of antibiotics with cytoplasmic targets (English)

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15 December 2017

author

Henrietta Venter

series ordinal

3

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15 December 2017

author name string

Thelma Ohene-Agyei

series ordinal

1

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15 December 2017

Jon D Lea

series ordinal

2

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15 December 2017

publication date

29 May 2012

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15 December 2017

FEMS Microbiology Letters

published in

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15 December 2017

volume

333

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15 December 2017

issue

1

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15 December 2017

page(s)

20-27

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15 December 2017

Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Site-directed mutagenesis reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Crystal structure of the multidrug efflux transporter AcrB at 3.1Å resolution reveals the N-terminal region with conserved amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Drug-induced conformational changes in multidrug efflux transporter AcrB from Haemophilus influenzae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

The choreography of multidrug export

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Structural and functional aspects of the multidrug efflux pump AcrB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Mutations in the central cavity and periplasmic domain affect efflux activity of the resistance-nodulation-division pump EmhB from Pseudomonas fluorescens cLP6a

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Substrate path in the AcrB multidrug efflux pump of Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Vestibules are part of the substrate path in the multidrug efflux transporter AcrB of Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Fitting periplasmic membrane fusion proteins to inner membrane transporters: mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Mechanisms of RND multidrug efflux pumps

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Pseudomonas aeruginosa: resistance to the max

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Drug transport mechanism of the AcrB efflux pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Functional rotation of the transporter AcrB: insights into drug extrusion from simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Chaperone-assisted crystallography with DARPins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

An ABC transporter with a secondary-active multidrug translocator domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Promiscuous partnering and independent activity of MexB, the multidrug transporter protein from Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

Role of Water during the Extrusion of Substrates by the Efflux Transporter AcrB

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1574-6968.2012.02594.X

10.1111/J.1574-6968.2012.02594.X

21 January 2018

Identifiers

DOI

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15 December 2017

PubMed ID

22568688

1 reference

15 December 2017