(Q45762060)

15 December 2017

title

Redefining the activity of a bone-specific transcription factor: novel insights for understanding bone formation (English)

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15 December 2017

3

Gary S Stein

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15 December 2017

author name string

Jane B Lian

series ordinal

1

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15 December 2017

Jonathan A Gordon

series ordinal

2

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15 December 2017

language of work or name

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1 October 2013

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15 December 2017

Journal of Bone and Mineral Research

published in

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15 December 2017

volume

28

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15 December 2017

issue

10

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15 December 2017

page(s)

2060-2063

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15 December 2017

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

cites work

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

21 January 2018

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Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia.

21 January 2018

1 reference

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

21 January 2018

1 reference

Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

21 January 2018

1 reference

Maturational disturbance of chondrocytes in Cbfa1-deficient mice

21 January 2018

1 reference

Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes

21 January 2018

1 reference

Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice

21 January 2018

1 reference

Induction of Osteoclast Differentiation by Runx2 through Receptor Activator of Nuclear Factor-κB Ligand (RANKL) and Osteoprotegerin Regulation and Partial Rescue of Osteoclastogenesis in Runx2–/– Mice by RANKL Transgene

21 January 2018

1 reference

Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

21 January 2018

1 reference

Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal.

21 January 2018

1 reference

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

21 January 2018

1 reference

Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene

21 January 2018

1 reference

Transactivation by Runt related factor-2 of matrix metalloproteinase-13 in astrocytes.

21 January 2018

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Expression of Runx2 transcription factor in non-skeletal tissues, sperm and brain

21 January 2018

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RUNX2 transcription factor regulates gene expression in luteinizing granulosa cells of rat ovaries

21 January 2018

1 reference

Parathyroid hormone-related protein protects renal tubuloepithelial cells from apoptosis by activating transcription factor Runx2.

21 January 2018

1 reference

An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice.

21 January 2018

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Chondrocyte-specific regulatory activity of Runx2 is essential for survival and skeletal development

21 January 2018

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Regulation of chondrocyte differentiation by Cbfa1

21 January 2018

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Role of Runx genes in chondrocyte differentiation

21 January 2018

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Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.

21 January 2018

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Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

21 January 2018

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Runx2 contributes to murine Col10a1 gene regulation through direct interaction with its cis-enhancer

21 January 2018

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Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes

21 January 2018

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Signaling networks in RUNX2-dependent bone development

21 January 2018

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Development of the endochondral skeleton

21 January 2018

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Regulation of bone and cartilage development by network between BMP signalling and transcription factors

21 January 2018

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Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function

21 January 2018

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Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes

21 January 2018

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SOX9 determines RUNX2 transactivity by directing intracellular degradation

21 January 2018

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Role of Runx proteins in chondrogenesis

21 January 2018

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Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures

21 January 2018

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High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage

21 January 2018

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Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog

21 January 2018

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Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.

21 January 2018

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Runx1 and Runx2 cooperate during sternal morphogenesis

21 January 2018

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A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

21 January 2018

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Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency

21 January 2018

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Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development

21 January 2018

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Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice

21 January 2018

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Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation

21 January 2018

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A Runx2 threshold for the cleidocranial dysplasia phenotype

21 January 2018

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Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.

21 January 2018

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ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome

21 January 2018

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Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors

21 January 2018

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The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

21 January 2018

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Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor.

21 January 2018

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Mitogen-activated protein kinase pathways in osteoblasts

21 January 2018

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Bookmarking the genome: maintenance of epigenetic information.

21 January 2018

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Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2.

21 January 2018

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MicroRNA control of bone formation and homeostasis

21 January 2018

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RUNX2 in mammary gland development and breast cancer.

21 January 2018

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Cbfa1/Runx2 expression in an ossifying basal cell carcinoma of the eyelid

21 January 2018

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Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells

21 January 2018

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Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions

21 January 2018

1 reference

Runx2 isoform I controls a panel of proinvasive genes driving aggressiveness of papillary thyroid carcinomas

21 January 2018

1 reference

Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene Expression

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JBMR.2076

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15 December 2017

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15 December 2017