(Q45772071)

15 December 2017

title

Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties (English)

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15 December 2017

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Hassan Issafras

1

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15 December 2017

John A Corbin

series ordinal

2

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15 December 2017

Ira D Goldfine

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3

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15 December 2017

Marina K Roell

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4

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15 December 2017

language of work or name

English

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publication date

5 November 2013

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15 December 2017

Journal of Pharmacology and Experimental Therapeutics

published in

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15 December 2017

volume

348

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15 December 2017

issue

1

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15 December 2017

page(s)

202-215

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15 December 2017

Rilonacept in the treatment of chronic inflammatory disorders

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Some quantitative uses of drug antagonists

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The many worlds of reducing interleukin-1

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12 December 2020

Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

A mutational analysis of receptor binding sites of interleukin-1 beta: differences in binding of human interleukin-1 beta muteins to human and mouse receptors.

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Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity.

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12 December 2020

Interleukin-1 blockade by anakinra improves clinical symptoms in patients with neonatal-onset multisystem inflammatory disease

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Biologic basis for interleukin-1 in disease

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A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

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Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra

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12 December 2020

Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1 beta by site-directed mutagenesis. Identification of a single site in IL-1ra and two sites in IL-1 beta.

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Allosteric modulation of muscarinic acetylcholine receptors.

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12 December 2020

One target-two different binding modes: structural insights into gevokizumab and canakinumab interactions to interleukin-1β

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Exploring "one-shot" kinetics and small molecule analysis using the ProteOn XPR36 array biosensor

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12 December 2020

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12 December 2020

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types

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IL-1 beta scavenging by the type II IL-1 decoy receptor in human neutrophils

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Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta

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12 December 2020

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

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Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

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12 December 2020

Extending the range of rate constants available from BIACORE: interpreting mass transport-influenced binding data

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G protein-coupled receptor allosterism and complexing

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12 December 2020

Why the Schild method is better than Schild realised

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12 December 2020

Anakinra: review of recombinant human interleukin-I receptor antagonist in the treatment of rheumatoid arthritis

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12 December 2020

Expanding the ProteOn XPR36 biosensor into a 36-ligand array expedites protein interaction analysis

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12 December 2020

Analysis of the binding of the Fab fragment of monoclonal antibody NC10 to influenza virus N9 neuraminidase from tern and whale using the BIAcore biosensor: effect of immobilization level and flow rate on kinetic analysis

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12 December 2020

Identifiers

DOI

10.1124/JPET.113.205443

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15 December 2017

PMC publication ID

6067399

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15 December 2017