(Q45848557)

16 December 2017

title

Of chimeric antigen receptors and antibodies: OX40 and 41BB costimulation sharpen up T cell-based immunotherapy of cancer (English)

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16 December 2017

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Andreas A Hombach

1

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16 December 2017

Hinrich Abken

series ordinal

2

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16 December 2017

publication date

1 July 2013

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16 December 2017

published in

Immunotherapy

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16 December 2017

volume

5

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16 December 2017

issue

7

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16 December 2017

page(s)

677-681

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16 December 2017

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

cites work

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Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

21 January 2018

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The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy

21 January 2018

1 reference

The T-body approach: redirecting T cells with antibody specificity

21 January 2018

1 reference

Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers

21 January 2018

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Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.

21 January 2018

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Science gone translational: the OX40 agonist story

21 January 2018

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Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function

21 January 2018

1 reference

SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ

21 January 2018

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Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors

21 January 2018

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Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.

21 January 2018

1 reference

CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe.

21 January 2018

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Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

21 January 2018

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Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

21 January 2018

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In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB)

21 January 2018

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Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28-OX40 signalling

21 January 2018

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Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

21 January 2018

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B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

21 January 2018

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T cells redirected by a CD3ζ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term

21 January 2018

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OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis.

21 January 2018

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Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right

21 January 2018

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OX40 is required for regulatory T cell-mediated control of colitis

21 January 2018

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OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

21 January 2018

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CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory t cells which can be overcome by preventing Lck activation

21 January 2018

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Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype

21 January 2018

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Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/IMT.13.54

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16 December 2017

release_ya2ctnbv2bf4hi2yuxohknvs74

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/ya2ctnbv2bf4hi2yuxohknvs74

mapped directly with Wikidata item

24 November 2022

based on heuristic

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16 December 2017