(Q45858516)

17 December 2017

title

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy (English)

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17 December 2017

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9

Reno Debets

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17 December 2017

John B A G Haanen

13

object named as

John B A G Haanen

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17 December 2017

author name string

Gavin M Bendle

1

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17 December 2017

Carsten Linnemann

2

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17 December 2017

Anna I Hooijkaas

3

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Laura Bies

4

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Moniek A de Witte

5

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Annelies Jorritsma

6

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Andrew D M Kaiser

7

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Nadine Pouw

8

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Elisa Kieback

10

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Wolfgang Uckert

11

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Ji-Ying Song

12

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Ton N M Schumacher

14

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17 December 2017

language of work or name

English

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publication date

18 April 2010

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17 December 2017

published in

Nature Medicine

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17 December 2017

volume

16

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issue

5

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17 December 2017

page(s)

565-70, 1p following 570

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/nm.2128

exact match

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cites work

Passive but not active CD8+ T cell-based immunotherapy interferes with liver tumor progression in a transgenic mouse model

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Targeting self-antigens through allogeneic TCR gene transfer

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Generation of T cell help through a MHC class I-restricted TCR.

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Cancer regression in patients after transfer of genetically engineered lymphocytes

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TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

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Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy.

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Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR.

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12 December 2020

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

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12 December 2020

TCR gene therapy of spontaneous prostate carcinoma requires in vivo T cell activation.

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12 December 2020

Selecting highly affine and well-expressed TCRs for gene therapy of melanoma

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12 December 2020

Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer

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12 December 2020

The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure

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12 December 2020

Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer

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12 December 2020

Adoptive immunotherapy for cancer: building on success

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12 December 2020

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

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12 December 2020

Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity

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12 December 2020

Immunotherapy through TCR gene transfer

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12 December 2020

Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.

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12 December 2020

Facilitating matched pairing and expression of TCR chains introduced into human T cells

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12 December 2020

Opposing effects of IL-2 in tumor immunotherapy: promoting CD8 T cell growth and inducing apoptosis

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12 December 2020

Preclinical development of T cell receptor gene therapy

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12 December 2020

A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer

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12 December 2020

A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection

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12 December 2020

Requirements for effective antitumor responses of TCR transduced T cells

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12 December 2020

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

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12 December 2020

Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability

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12 December 2020

Progress in human tumour immunology and immunotherapy

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12 December 2020

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

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12 December 2020

Transfusion-associated graft-versus-host disease

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12 December 2020

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes

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12 December 2020

Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model

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12 December 2020

Transfusion-associated graft-versus-host disease in immunocompetent patients: case series and review of the literature.

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12 December 2020

Biodistribution and retention time of retrovirally labeled T lymphocytes in mice is strongly influenced by the culture period before infusion

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12 December 2020

Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells.

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12 December 2020

TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008.

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12 December 2020

Molecular design of the Calphabeta interface favors specific pairing of introduced TCRalphabeta in human T cells

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12 December 2020

Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes.

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12 December 2020

A mouse model of lymphocyte infusion-induced bone marrow failure

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12 December 2020

Transfusion-associated graft-versus-host disease: historical perspectives, incidence, and current use of irradiated blood products

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12 December 2020

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

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12 December 2020

T-cell-receptor gene therapy

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12 December 2020

Identifiers

DOI

10.1038/NM.2128

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17 December 2017

Dimensions Publication ID

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17 December 2017