(Q45862207)

17 December 2017

title

Exogenous IL-10 overexpression reduces perforin production by activated allogenic CD8+ cells and prolongs cardiac allograft survival (English)

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17 December 2017

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Kiyohiro Oshima

1

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17 December 2017

Guanggen Cui

2

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17 December 2017

Thomas Tung

3

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17 December 2017

Onisuru Okotie

4

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17 December 2017

Hillel Laks

5

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17 December 2017

Luyi Sen

6

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17 December 2017

publication date

1 September 2006

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17 December 2017

American Journal of Physiology Heart and Circulatory Physiology

published in

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17 December 2017

volume

292

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17 December 2017

issue

1

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17 December 2017

page(s)

H277-84

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17 December 2017

Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.

cites work

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Unlocking the secrets of CTL and NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Perforin and the granule exocytosis cytotoxicity pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Liposome-mediated combinatorial cytokine gene therapy induces localized synergistic immunosuppression and promotes long-term survival of cardiac allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Identification of an astrocyte cell population from human brain that expresses perforin, a cytotoxic protein implicated in immune defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Localized immunosuppression in the cardiac allograft induced by a new liposome-mediated IL-10 gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Perforin: structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Localized interleukin-10 gene transfer induces apoptosis of alloreactive T cells via FAS/FASL pathway, improves function, and prolongs survival of cardiac allograft

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

A central role of perforin in cytolysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Efficiency, efficacy, and adverse effects of adenovirus vs. liposome-mediated gene therapy in cardiac allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Intragraft activation of genes encoding cytotoxic T lymphocyte effector molecules precedes the histological evidence of rejection in human cardiac transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Granzymes: exogenous proteinases that induce target cell apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

Dual upregulation of Fas and Bax promotes alloreactive T cell apoptosis in IL-10 gene targeting of cardiac allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00441.2006

10.1152/AJPHEART.00441.2006

21 January 2018

Identifiers

DOI

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17 December 2017

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17 December 2017